Bioorganic and Medicinal Chemistry Letters p. 1831 - 1836 (1996)
Update date:2022-08-17
Topics:
Searcey, Mark
Martin, P. Noel
Howarth, Nicola M.
Madden, Bernie
Wakelin, Laurence P. G.
A series of 9-anilinoacridine-4-carboxamides with cycloalkyl sidechains has been synthesised to study the effect of sidechain bulk on the DNA binding properties and biological activity of these potential threading intercalators. With sidechains larger than cyclohexane the pKa of the acridine is exceptionally low, so that DNA binding is restricted to pHs below 5. The compounds are cytotoxic to human colon carcinoma cells in the μM range irrespective of their ability to bind to DNA.
View More
Shandong Loyal Chemical industrial Co.,Ltd
Contact:0533-7451788
Address:Linzi Chemical Industrial Park, Zibo, Shandong Province
KAIYUAN CHEMICAL COMPANY LIMITED.
website:http://www.kaiyuanchem.com
Contact:+86-22-59891255/66/77
Address:B-2205, Kuangshi International Building, Yingbin Road, XiangLuo Bay Business District, Binhai New area, Tianjin, China.
Xinxiang Junlong Biological Technology Co., Ltd.
website:https://junlongbio.lookchem.com/
Contact:86-13525059581
Address:Xinxiang City, Henan Province
Contact:(86) 731 88718666
Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
JIAXING SUNS INTERNATIONAL TRADE CO LTD
Contact:18367306858
Address:No.123,Huixin Avenue,Huimin Dist
Doi:10.1021/jo0010330
(2001)Doi:10.1080/004982598239632
(1998)Doi:10.1016/S0039-128X(75)80026-2
(1975)Doi:10.1039/b312301d
(2004)Doi:10.1016/S1872-2067(15)61055-5
(2016)Doi:10.1039/c6cc05592c
(2016)
