Research on Chemical Intermediates p. 6079 - 6098 (2017)
Update date:2022-08-11
Topics:
Pogaku, Vinay
Eslavath, Ravi Kumar
Dayakar
Singh, Surya S.
Basavoju, Srinivas
Novel triazole substituted pyrazolyl-methylenehydrazinyl-5-arylidene thiazolidinone derivatives 6a–n and 7a–l were synthesized and characterized by Fourier transform infrared, 1H and 13C nuclear magnetic resonance, mass spectrometry and elemental (CHN) analysis. The in vitro antibacterial (6a–n and 7a–l) and cytotoxic (6a–n) activities were evaluated for these compounds. The results revealed that the compounds 6b, 6i, 6k, 7b, 7h displayed good antibacterial activity. The compounds 6c (IC50?=?5.4?μM), 6l (IC50?=?6.3?μM) and 6f (IC50?=?9.85?μM) were effective for inhibition of human breast cancer cell line MCF-7. Similarly, the compounds 6b (IC50?=?8.7?μM) and 6c (IC50?=?9.06?μM) were shown to have effective inhibition on human cervical cancer cell line Hela.
View MoreShandong Xingshun New Material Co., Ltd.
website:http://www.sd-xingshun.com
Contact:+86-519-86461196/+86-519-86464994
Address:Middle of Luhua East Road, Dingtao District
Contact:+86-13914766747
Address:Floors 21&22, Jin Cheng Tower, No. 216 Middle Longpan Road, Nanjing
Hangzhou innopharma technology Co,.Ltd.
Contact:+86-13388601988
Address:Room845,lixin building, moganshan road, hangzhou, china
Changzhou Medi-tech Bioscientific Co., Ltd.
Contact:86-519-83246372
Address:Number 115 Menghedadao Road, Changzhou, Jiangsu, China
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address: Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Doi:10.1002/hlca.200690080
(2006)Doi:10.1039/b109645a
(2002)Doi:10.1016/S0040-4039(00)98877-4
(1985)Doi:10.1016/S0040-4039(97)10836-X
(1998)Doi:10.1021/acs.jmedchem.5b01935
(2016)Doi:10.1016/j.carres.2016.02.009
(2016)