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Gentamycin sulfate

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Name

Gentamycin sulfate

EINECS 215-778-9
CAS No. 1405-41-0 Density ==
PSA 719.38000 LogP -1.26180
Solubility water: 50 mg/mL Melting Point 218-237 °C
Formula C21H43N5O7.H2SO4 Boiling Point 797.6 °C at 760 mmHg
Molecular Weight 575.67 Flash Point 436.2 °C
Transport Information N/A Appearance White crystalline powder
Safety 23-36/37-45-22-24/25 Risk Codes 42/43
Molecular Structure Molecular Structure of 1405-41-0 (Gentamycin sulfate) Hazard Symbols HarmfulXn
Synonyms

Gentalline;Pred-G S.O.P.;Gentocin (Veterinary);Gentocin (*sulfate*);Garamycin (TN);Gentacin;Geramycin;Gentocin;Prestwick_240;Septopal;Gentamicin,sulfate (salt);Gentamicin C complex sulfate;Gentamicins;Topagen (Veterinary);Gentamycin sulphat;Gentamycin Solution;Gentamicin sulphate;Alcomicin;Garasol (Veterinary);

 

Gentamycin sulfate Chemical Properties

Formula of Gentamycin sulfate (CAS NO.1405-41-0): C21H43N5O7.H2SO4
Molecular Weight: 575.67
Flash Point: 436.2 °C
Enthalpy of Vaporization: 132.12 kJ/mol
Boiling Point: 797.6 °C at 760 mmHg
Melting point: 218-237 °C(lit.)
Structure of Gentamycin sulfate (CAS NO.1405-41-0):
                    
IUPAC Name: 2-[4,6-Diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; sulfuricacid

Gentamycin sulfate Uses

 Gentamycin sulfate (CAS NO.1405-41-0) can be used as biochemical reagent, for example in some medicine use, as the antibacterial medicine. And it can be the medicine for the treatment of sepsis, urinary tract infection, staphylococcus infection, endocarditis and other diseases.

Gentamycin sulfate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 600mg/kg (600mg/kg)   Chemotherapy Vol. 16, Pg. 105, 1968.
man TDLo intravenous 21mg/kg/6D-I (21mg/kg)   Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.
mouse LD50 intracrebral 17300ug/kg (17.3mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Chemotherapy Vol. 15, Pg. 483, 1967.
mouse LD50 intramuscular 250mg/kg (250mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse LD50 intraperitoneal 245mg/kg (245mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse LD50 intravenous 47mg/kg (47mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse LD50 oral > 11269mg/kg (11269mg/kg)   Drugs in Japan Vol. 6, Pg. 268, 1982.
mouse LD50 subcutaneous 478mg/kg (478mg/kg)   Journal of Antibiotics. Vol. 23, Pg. 551, 1970.
rat LD50 intramuscular 384mg/kg (384mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intraperitoneal 630mg/kg (630mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Japanese Journal of Antibiotics. Vol. 26, Pg. 221, 1973.
rat LD50 intravenous 96mg/kg (96mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat LD50 subcutaneous 873mg(base)/k (873mg/kg)   Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(9), Pg. 26, 1990.
women TDLo intravenous 45mg/kg/1W-I (45mg/kg)   Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.
 

Gentamycin sulfate Safety Profile

GENTAMYCIN sulfate's human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx.
Hazard Symbols of Gentamycin sulfate (CAS NO.1405-41-0): HarmfulXn 
Risk Codes: R42/43 
R42/43:May cause sensitization by inhalation and skin contact. 
Safety Description: S23;S36/37;S45 
S23:Do not breathe vapour. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Gentamycin sulfate Specification

 Gentamycin sulfate , its cas register number is 1405-41-0. It also can be called Garamycin ; and 2-[4,6-Diamino-3-[3-amino-6-(1-methylaminoethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-methylamino-oxane-3,5-diol sulphate .

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