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Gramicidin

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Name

Gramicidin

EINECS 215-790-4
CAS No. 1405-97-6 Density 1.24g/cm3
PSA 548.99000 LogP 11.26260
Solubility Soluble in acetic acid and lower alcohols. Practically insoluble in water. Melting Point 229-230℃
Formula C99H140N20O17 Boiling Point 1394.8°C at 760 mmHg
Molecular Weight 1882.32 Flash Point 797.4°C
Transport Information N/A Appearance white powder
Safety 26-36-24/25-22 Risk Codes 20/21-36/37/38
Molecular Structure Molecular Structure of 1405-97-6 (Gramicidin) Hazard Symbols HarmfulXn
Synonyms

Gramicidins;Gramoderm;Gramicidinum;

Article Data 2

Gramicidin Synthetic route

C119H172N20O25

1405-97-6

Gramicidin A

Conditions
ConditionsYield
With chlorotriisopropylsilane; water; trifluoroacetic acid; phenol In dichloromethane at 25℃; for 1h; Inert atmosphere;

C117H166N19O24Pol

141-43-5

ethanolamine

1405-97-6

Gramicidin A

Conditions
ConditionsYield
Stage #1: C117H166N19O24Pol With trifluoroacetic acid In water at 20℃; hydroxymethylbenzoic acid-TentaGel macrobeads;
Stage #2: ethanolamine In N,N-dimethyl-formamide at 50℃; hydroxymethylbenzoic acid-TentaGel macrobeads;
1405-97-6

Gramicidin A

C99(2)H140N20O17

Conditions
ConditionsYield
With deuteromethanol for 24h;

Gramicidin Specification

The systematic name of Gramicidin is Gramicidin. With the CAS registry number 1405-97-6, it is also named as Gramicidinum. The product's categories are A-KAntibiotics; Antibacterial; Antibiotics A to; Antibiotics G-MAntibiotics; Chemical Structure Class; Inhibits an EnzymeAntibiotics; Interferes with Cell Membrane Permeability (Ionophores)Antibiotics; Mechanism of Action; Peptides; Spectrum of Activity; Peptides Multi-Drug Resistance; Substrates for Drug Efflux Pumps; Drug Efflux Pumps. Besides, it is a heterogeneous mixture of six antibiotic compounds, which should be stored at 2-8 °C. In addition, its molecular formula is C99H140N20O17 and molecular weight is 1882.2947.

Uses of Gramicidin: this chemical is active against Gram-positive bacteria, except for the Gram-positive bacilli. It is also against select Gram-negative organisms, such as Neisseria bacteria. Furthermore, it can be used primarily as a topical antibiotic.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. It is also harmful by inhalation and in contact with skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing. Moreover, please do not breathe dust. And you should avoid contact with skin and eyes.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CC(C)CC(C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(CC(C)C)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)NCCO)NC(=O)C(C)NC(=O)CNC(=O)C(C(C)C)NC=O
(2)Isomeric SMILES: C[C@@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC7=CNC8=CC=CC=C87)C(=O)NCCO)NC(=O)CNC(=O)[C@H](C(C)C)NC=O
(3)InChI: InChI=1S/C99H140N20O17/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83-,84+,85-/m0/s1
(4)InChIKey: ZWCXYZRRTRDGQE-SORVKSEFSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1500ug/kg (1.5mg/kg)   Science. Vol. 103, Pg. 419, 1946.
mouse LD50 parenteral 17ug/kg (0.017mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1542, 1978.
mouse LDLo intraperitoneal 20mg/kg (20mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental

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