1. Introduction of Hexahydrophthalic anhydride
Hexahydrophthalic anhydride, with the CAS registry number 85-42-7, is also known as 1,2-Cyclohexanedicarboxylic acid anhydride, 1,3-Isobenzofurandione, hexahydro-. It belongs to the product categories of Diels-Alder Adducts; Organics. What's more, its systematic name is Hexahydro-2-benzofuran-1,3-dione. Hexahydrophthalic anhydride can be used as coatings, epoxy curing agent, polyester resin, adhesive, plasticizer, intermediate of plasticizers and insect repellents. This chemical should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from moisture, sunburn and fire.

2. Properties of Hexahydrophthalic anhydride
(1)ACD/LogP: 0.762; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.76; (4)ACD/LogD (pH 7.4): 0.76; (5)ACD/BCF (pH 5.5): 2.24; (6)ACD/BCF (pH 7.4): 2.24; (7)ACD/KOC (pH 5.5): 61.91; (8)ACD/KOC (pH 7.4): 61.91; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 43.37 Å²; (13)Index of Refraction: 1.502; (14)Molar Refractivity: 36.813 cm³; (15)Molar Volume: 124.728 cm³; (16)Polarizability: 14.594×10^-24cm³; (17)Surface Tension: 42.23 dyne/cm; (18)Density: 1.236 g/cm³; (19)Flash Point: 143.909 °C; (20)Enthalpy of Vaporization: 52.227 kJ/mol; (21)Boiling Point: 283.351 °C at 760 mmHg; (22)Vapour Pressure: 0.003 mmHg at 25°C.

3. Structure Descriptors of Hexahydrophthalic anhydride
(1)SMILES: O=C1OC(=O)C2C1CCCC2
(2)Std. InChI: InChI=1S/C8H10O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h5-6H,1-4H2
(3)Std. InChIKey: MUTGBJKUEZFXGO-UHFFFAOYSA-N

4. Safety Information of Hexahydrophthalic anhydride
Hazard Symbols:Xn
Risk Codes:
R41:Risk of serious damage to the eyes. 
R42/43:May cause sensitization by inhalation and skin contact.
Safety Description:
S23:Do not breathe vapour. 
S24:Avoid contact with skin. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39:Wear suitable gloves and eye/face protection.

5. Preparation of Hexahydrophthalic anhydride
Hexahydrophthalic anhydride can be prepared by cyclohex-1-ene-1,2-dicarboxylic acid anhydride at the temperature of 95 °C. This reaction will need reagent H₂ and solvent dimethylformamide with the reaction time of 3 hours. This reaction will also need catalyst Raney-Ni. The yield is about 88%.

6. Uses of Hexahydrophthalic anhydride
Hexahydrophthalic anhydride can be used to produce 2-trichloroacetyl-1-cyclohexanecarboxylic acid at the temperature of 60 °C. It will need reagent dibenzo-18-crown-6 and solvent acetonitrile with the reaction time of 6 hours. The yield is about 81%.

7. Other details of Hexahydrophthalic anhydride
When you are using this chemical, please be cautious about it as the following:
Hexahydrophthalic anhydride has a risk of serious damage to eyes and it may cause sensitisation by inhalation and skin contact. You should not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer). When using it, you must avoid contact with skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective gloves and eye/face protection.