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Hydromorphone hydrochloride

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  • Name Hydromorphone hydrochloride
  • EINECS200-762-6
  • CAS No. 71-68-1
  • Density1.1451 (rough estimate)
  • PSA49.77000
  • LogP2.37020
  • SolubilityN/A
  • Melting Point>280°C (dec.)
  • FormulaC17H19NO3.ClH
  • Boiling Point475.6 °C at 760 mmHg
  • Molecular Weight321.804
  • Flash Point241.4 °C
  • Transport InformationN/A
  • AppearanceN/A
  • Safety16-36/37-45
  • Risk Codes22
  • Molecular Structure
    Molecular Structure of 71-68-1 (HYDROMORPHONE HYDROCHLORIDE)
  • Hazard SymbolsHarmfulXn
  • SynonymsHarmfulXn
  • Article Data6

Hydromorphone hydrochloride History

 Dilaudid (71-68-1) was first synthesized and researched in Germany in 1924 and introduced to the mass market by Knoll in 1926 under the brand name Dilaudid indicating its derivation and degree of similarity to morphine (by way of laudanum)—Cf. Dicodid (hydrocodone), Dihydrin (dihydrocodeine) and Dinarkon (oxycodone). Some authorities and publications use the name dilaudid as a synecdoche (e.g. like Kleenex for tissues, Xerox for copies &c.) for hydromorphone. Hydromorphone may also be known by the brand name Morphodid.

Hydromorphone hydrochloride Specification

The CAS registry number of Dilaudid is 71-68-1. Its EINECS registry number is 200-762-6. The systematic name is (5α)-3-hydroxy-17-methyl-4,5-epoxymorphinan-6-one hydrochloride. In addition, the molecular formula is C17H19NO3.ClH. What's more, it is an opioid analgesic and it has a shorter duration of action than morphine. Besides, it should be stored in sealed container, and put in a cool and dry place.

Physical properties about Dilaudid are: (1)ACD/LogP: 1.06; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 4; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 1; (6)Polar Surface Area: 38.77 Å2; (7)Flash Point: 241.4 °C; (8)Enthalpy of Vaporization: 76.74 kJ/mol; (9)Boiling Point: 475.6 °C at 760 mmHg; (10)Vapour Pressure: 1.14E-09 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed. During using it, wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.). And you should keep it away from sources of ignition and no smoking.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.O=C4[C@@H]5Oc1c2c(ccc1O)C[C@H]3N(CC[C@]25[C@H]3CC4)C
(2)InChI: InChI=1/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1
(3)InChIKey: XHILEZUETWRSHC-NRGUFEMZBH

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 3mg/kg (3mg/kg) BEHAVIORAL: ANALGESIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
mouse LD50 intravenous 55mg/kg (55mg/kg)   Toxicology and Applied Pharmacology. Vol. 6, Pg. 334, 1964.
mouse LD50 subcutaneous 120mg/kg (120mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 238, 1953.
rabbit LDLo intravenous 2500ug/kg (2.5mg/kg) BEHAVIORAL: ANALGESIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
rat LD50 subcutaneous 51mg/kg (51mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 238, 1953.

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