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IUPAC Name: (2S)-2-Amino-5-[[2-hydroxy-1-[[(1R)-2-methylenecyclopropyl]methyl]-2-oxo-ethyl]amino]-5-oxo-pentanoic acid
Synonyms of Hypoglycine B (CAS NO.502-37-4) : g-L-Glutamyl-a-amino-b-(2-methylenecyclopropyl)propionic Acid Dipeptide ; g-L-Glutamylhypoglycine ; Hypoglycine B
CAS NO: 502-37-4
Molecular Formula:C12H18N2O5
Molecular Weight :270.2817
Molecular Structure :
Index of Refraction: 1.562
Surface Tension: 61.7 dyne/cm
Density: 1.33 g/cm3
Flash Point: 312.3 °C
Enthalpy of Vaporization: 96.56 kJ/mol
Boiling Point: 592.8 °C at 760 mmHg
Vapour Pressure: 1.38E-15 mmHg at 25°C
Hypoglycine B (CAS NO.502-37-4) is toxic if ingested and is a causative agent of Jamaican Vomiting Sickness. It is an amino acid and chemically related to lysine.
Hypoglycin B is a naturally occurring organic compound in the species Blighia sapida. It is particularly concentrated in the fruit of the plant especially in the seeds.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LDLo | intravenous | 160mg/kg (160mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 121, Pg. 272, 1957. |
rabbit | LDLo | intravenous | 25mg/kg (25mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA ENDOCRINE: HYPOGLYCEMIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 121, Pg. 272, 1957. |
rat | LDLo | intravenous | 200mg/kg (200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 121, Pg. 272, 1957. |
Poison by intravenous route. An experimental teratogen. Other experimental reproductive effects. When Hypoglycine B (CAS NO.502-37-4) is heated to decomposition,S37/39:Wear suitable gloves and eye/face protection. it emits toxic fumes of NOx.