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| Name |
Iopramine hydrochloride |
EINECS | 248-002-2 |
| CAS No. | 26786-32-3 | Density | g/cm3 |
| PSA | 23.55000 | LogP | 6.64850 |
| Solubility | Soluble in DMSO: ~24 mg/mL | Melting Point |
152-154° |
| Formula | C26H27 Cl N2 O . Cl H | Boiling Point | 575 °C at 760 mmHg |
| Molecular Weight | 455.46 | Flash Point | 301.6 °C |
| Transport Information | N/A | Appearance | off-white solid |
| Safety | Poison by intraperitoneal route. Experimental reproductive effects. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl. See also AMINES. | Risk Codes | 22-37-53 |
| Molecular Structure |
|
Hazard Symbols | Xn |
| Synonyms |
Acetophenone,4'-chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride (8CI); Ethanone,1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-,monohydrochloride (9CI); Gamanil; Gamonil; Leo 640 hydrochloride; Lofepraminehydrochloride; Lopramine hydrochloride; Timelit; Tymelyt; WHR 2908A |
Iopramine hydrochloride Chemical Properties
IUPAC Name: 1-(4-Chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone hydrochloride
Synonyms of Iopramine hydrochloride (CAS NO.26786-32-3) : 1-(4-Chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl](methyl)amino}ethanone hydrochloride (1:1) ; 4'-Chloro-2-((3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl)methylamino)acetophenone Monohydrochloride ; 5-(3-((p-Chlorobenzoylmethyl)-N-methylamino)propyl)-5H-dibenz[b,f]azepine Hydrochloride ; Amplit ; Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-, hydrochloride (1:1) ; Gamanil ; Lopramine Hydrochloride
CAS NO:26786-32-3
Molecular Formula:C26H28Cl2N2O
Molecular Weight :455.42
Molecular Structure :
EINECS: 248-002-2
Flash Point: 301.6 °C
Enthalpy of Vaporization: 86.14 kJ/mol
Boiling Point: 575 °C at 760 mmHg
Vapour Pressure: 3.17E-13 mmHg at 25°C
Storage temp: 2-8°C
Solubility : DMSO: ~24 mg/mL
Appearance: Iopramine hydrochloride (CAS NO.26786-32-3) is off-white solid.
Iopramine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 920mg/kg (920mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976. | |
| mouse | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970. | |
| rat | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970. | |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 10, Pg. 877, 1976. | |
| rat | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970. |
Iopramine hydrochloride Safety Profile
Poison by intraperitoneal route. Experimental reproductive effects. An experimental teratogen. Mutation data reported. When Iopramine hydrochloride (CAS NO.26786-32-3) is heated to decomposition, it emits toxic fumes of NOx and HCl. See also AMINES.
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