Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Ketorolac

Related Products

Hot Products

Name

Ketorolac

EINECS 200-001-2
CAS No. 74103-06-3 Density 1.398 g/cm3
PSA 59.30000 LogP 2.29100
Solubility 183mg/L(32 oC) Melting Point 160-161 ºC
Formula C15H13NO3 Boiling Point 223.7 ºC at 760 mmHg
Molecular Weight 255.273 Flash Point 89.1 ºC
Transport Information N/A Appearance white crystalline or white powder
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 74103-06-3 (Ketorolac) Hazard Symbols N/A
Synonyms

1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-, (?à)-;1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-;(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;(+-)-Ketorolac;

Article Data 27

Ketorolac Synthetic route

157071-66-4

Methyl isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

74103-06-3

Ketorolac

Conditions
ConditionsYield
With sodium hydroxide In methanol Ambient temperature;99%

ketorolac tromethamine

74103-06-3

Ketorolac

Conditions
ConditionsYield
With hydrogenchloride In water98%
With hydrogenchloride In water at 0 - 20℃;83.6%
With hydrogenchloride In water
140947-23-5

diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate

74103-06-3

Ketorolac

Conditions
ConditionsYield
Stage #1: diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate With sodium hydroxide In diethyl ether; water for 24h; Reflux;
Stage #2: With hydrogenchloride In ethyl acetate at 70℃; for 4h;
80%
With sodium hydroxide In tetrahydrofuran for 9h; Time; Reflux; Green chemistry;47.5%
With hydrogenchloride; sodium hydroxide 1.) ether, reflux, 24 h, 2.) ethyl acetate, 70 deg C, 4 h; Yield given. Multistep reaction;
66635-74-3

5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-carboxylic acid-2-propyl ester

74103-06-3

Ketorolac

Conditions
ConditionsYield
With potassium carbonate In methanol; water for 0.5h; Heating;64%
With water In methanol; aq. phosphate buffer at 37℃; pH=8; Kinetics; pH-value;
84023-60-9

5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

74103-06-3

Ketorolac

Conditions
ConditionsYield
With hydrogen; magnesium oxide; palladium on activated charcoal In methanol; water under 760 Torr; for 2h; Ambient temperature; Yield given;
80965-05-5

2-[2-(2-Benzoyl-5-methanesulfonyl-pyrrol-1-yl)-ethyl]-malonic acid dimethyl ester

74103-06-3

Ketorolac

Conditions
ConditionsYield
Yield given. Multistep reaction;
108061-03-6

ketorolac acid ethyl ester

74103-06-3

Ketorolac

Conditions
ConditionsYield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;

ketorolac acid <(N,N-dimethylamino)carbonyl>methyl ester

74103-06-3

Ketorolac

Conditions
ConditionsYield
With pooled human serum In water at 37℃; Rate constant; serum metabolism; other reagents and solvent, other temperatures;
1885-14-9

phenyl chloroformate

74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
2: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
3: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
157071-48-2

(1H-pyrrol-2-yl)acetic acid isopropyl ester

74103-06-3

Ketorolac

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 96 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -70 deg C, 1 h
2: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 15 h
3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
4: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 1.) oxalyl chloride / 1.) ether, ice-bath cooling, 0.75 h, 2.) CH2Cl2, r.t., 40 h
2: 97 percent / LDA / tetrahydrofuran / 1.) -75 deg C to -60 deg C, 2.) -65 deg C to 0 deg C, ca. 0.5 h
3: 68 percent / K2CO3, n-Bu4NBr / 44 h / Heating
4: 99 percent / 1 N NaOH / methanol / Ambient temperature
View Scheme

Ketorolac Chemical Properties


IUPAC Name: 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Molecular Formula: C15H13NO3
Molecular Weight: 255.27 g/mol
SMILES: n12c([C@@H](C(O)=O)CC2)ccc1C(c1ccccc1)=O
InChI: InChI=1/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
Classification Code: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cyclooxygenase Inhibitors; Drug / Therapeutic Agent; Enzyme Inhibitors; Peripheral Nervous System Agents; Sensory System Agents
Product Categories: API's
Index of Refraction: 1.436 
Molar Refractivity: 30.52 cm
Molar Volume: 116.6 cm3 
Polarizability: 12.1×10-24 cm3 
Surface Tension: 28.4 dyne/cm 
Density: 1.398 g/cm3 
Flash Point: 89.1 °C 
Enthalpy of Vaporization: 46.02 kJ/mol 
Boiling Point: 223.7 °C at 760 mmHg 
Melting Point: 160-161 °C
Vapour Pressure of Ketorolac (CAS NO.74103-06-3): 0.0947 mmHg at 25 °C

Ketorolac Uses

 Ketorolac (CAS NO.74103-06-3) is a non-steroidal anti-inflammatory drug, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. An ophthalmic (i.e., eye-drop) solution of Ketorolac is available and is used to treat eye pain and to relieve the itchiness and burning of seasonal allergies.

Ketorolac Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 200mg/kg (200mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.
mouse LDLo intraperitoneal 100mg/kg (100mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.
 

Ketorolac Safety Profile

RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup of Ketorolac (CAS NO.74103-06-3): II

Ketorolac Specification

 Ketorolac (CAS NO.74103-06-3), its Synonyms are (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid ; (+-)-Ketorolac ; Ketorolacum ; 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)- .

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 74103-06-3