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Basic Information
| CAS No.: | 34552-83-5 |
|---|---|
| Name: | Loperamide hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | C29H33ClN2O2.HCl |
| Molecular Weight: | 513.507 |
| Synonyms: | Imodium;1-Piperidinebutanamide,4-(4-chlorophenyl)-4- hydroxy-N,N-dimethyl-R,R-diphenyl-,monohydrochloride;Imodium (TN);Lopemin;Prestwick_302;4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide hydrochloride;R 18553;Loperamide hydrochloride (JAN/USP);Loperamide HCl; |
| EINECS: | 252-082-4 |
| Density: | == |
| Melting Point: | 223-225 °C |
| Boiling Point: | 647.2 °C at 760 mmHg |
| Flash Point: | 345.2 °C |
| Appearance: | White solid |
| Hazard Symbols: |
 T
|
| Risk Codes: | 25 |
| Safety: | 45 |
| Transport Information: | UN 2811 6.1/PG 3 |
| PSA: | 43.78000 |
| LogP: | 5.82790 |
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Synthetic route
- 39512-49-7
4-(4-chlorophenyl)-4-hydroxypiperidine
- 37743-18-3
N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide
- 34552-83-5
loperamide hydrochloride
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 4-(4-chlorophenyl)-4-hydroxypiperidine With sodium carbonate; potassium iodide In 1,3-dioxolane-4-methanol for 0.25h; Stage #2: N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide In 1,3-dioxolane-4-methanol at 60℃; for 2h; Stage #3: With hydrogenchloride In 1,3-dioxolane-4-methanol; isopropyl alcohol for 0.333333h; | 67% |
- 39512-49-7
4-(4-chlorophenyl)-4-hydroxypiperidine
- 37743-18-3
N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide
- 108-10-1
4-methyl-2-pentanone
- 34552-83-5
loperamide hydrochloride
Conditions
| Conditions | Yield |
|---|---|
| With potassium iodide; sodium carbonate In hydrogenchloride; isopropyl alcohol; acetone; toluene |
...Expand
Conditions
| Conditions | Yield |
|---|---|
| With tetra-(n-butyl)ammonium iodide; sodium hydroxide In dichloromethane; water at 20℃; Inert atmosphere; | A 14% B 44% |
...Expand
Raw Materials
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Loperamide hydrochloride
Chemistry
The Molecular formula of LOPERAMIDE HYDROCHLORIDE(34552-83-5): C29H34Cl2N2O2
The Molecular Weight of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 513.5
The Molecular Structure of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
EINECS: 252-082-4
Melting point: 223-225°C
Boiling Point: 647.2 °C at 760 mmHg
Flash Point: 345.2 °C
Enthalpy of Vaporization: 100.3 kJ/mol
Vapour Pressure: 1.23E-17 mmHg at 25°C
Appearance: White Solid
IUPAC Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Synonyms: 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTANAMIDE HYDROCHLORIDE;4-(4-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-;LOPERAMIDE HYDROCHLORIDE;4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINBUTYRAMIDE HYDROCHLORIDE;LABOTEST-BB LT00134703;LOSERAMIN;LOPERAMIDE HCL;
The Molecular Weight of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 513.5
The Molecular Structure of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
EINECS: 252-082-4
Melting point: 223-225°C
Boiling Point: 647.2 °C at 760 mmHg
Flash Point: 345.2 °C
Enthalpy of Vaporization: 100.3 kJ/mol
Vapour Pressure: 1.23E-17 mmHg at 25°C
Appearance: White Solid
IUPAC Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Synonyms: 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTANAMIDE HYDROCHLORIDE;4-(4-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-;LOPERAMIDE HYDROCHLORIDE;4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINBUTYRAMIDE HYDROCHLORIDE;LABOTEST-BB LT00134703;LOSERAMIN;LOPERAMIDE HCL;
Uses
LOPERAMIDE HYDROCHLORIDE(34552-83-5) is used as antidiarrheal drugs.
Toxicity Data With Reference
The Toxicity Information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
| 1. | orl-cld TDLo:125 µg/kg | BMJOAE British Medical Journal. 294 (1987),1383. | ||
| 2. | orl-rat LD50:185 mg/kg | JMCMAR Journal of Medicinal Chemistry. 16 (1973),782. | ||
| 3. | scu-rat LD50:78,700 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
| 4. | ivn-rat LD50:7490 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
| 5. | orl-mus LD50:105 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1633. | ||
| 6. | ipr-mus LD50:28 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1633. | ||
| 7. | scu-mus LD50:75 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1636. | ||
| 8. | ivn-mus LD50:12,600 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
| 9. | orl-gpg LD50:41,500 µg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),1204. |
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and HCl.}
The Hazard Codes of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
T
HazardClass: 6.1(b)
The Risk Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
25: Toxic if swallowed
The Safety Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TM4960000
PackingGroup: III
The Hazard Codes of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
T HazardClass: 6.1(b)
The Risk Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
25: Toxic if swallowed
The Safety Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TM4960000
PackingGroup: III