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CAS No.: | 34552-83-5 |
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Name: | Loperamide hydrochloride |
Molecular Structure: | |
Formula: | C29H33ClN2O2.HCl |
Molecular Weight: | 513.507 |
Synonyms: | Imodium;1-Piperidinebutanamide,4-(4-chlorophenyl)-4- hydroxy-N,N-dimethyl-R,R-diphenyl-,monohydrochloride;Imodium (TN);Lopemin;Prestwick_302;4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide hydrochloride;R 18553;Loperamide hydrochloride (JAN/USP);Loperamide HCl; |
EINECS: | 252-082-4 |
Density: | == |
Melting Point: | 223-225 °C |
Boiling Point: | 647.2 °C at 760 mmHg |
Flash Point: | 345.2 °C |
Appearance: | White solid |
Hazard Symbols: | T |
Risk Codes: | 25 |
Safety: | 45 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 43.78000 |
LogP: | 5.82790 |
4-(4-chlorophenyl)-4-hydroxypiperidine
N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide
loperamide hydrochloride
Conditions | Yield |
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Stage #1: 4-(4-chlorophenyl)-4-hydroxypiperidine With sodium carbonate; potassium iodide In 1,3-dioxolane-4-methanol for 0.25h; Stage #2: N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide In 1,3-dioxolane-4-methanol at 60℃; for 2h; Stage #3: With hydrogenchloride In 1,3-dioxolane-4-methanol; isopropyl alcohol for 0.333333h; | 67% |
4-(4-chlorophenyl)-4-hydroxypiperidine
N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide
4-methyl-2-pentanone
loperamide hydrochloride
Conditions | Yield |
---|---|
With potassium iodide; sodium carbonate In hydrogenchloride; isopropyl alcohol; acetone; toluene |
Conditions | Yield |
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With tetra-(n-butyl)ammonium iodide; sodium hydroxide In dichloromethane; water at 20℃; Inert atmosphere; | A 14% B 44% |
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1. | orl-cld TDLo:125 µg/kg | BMJOAE British Medical Journal. 294 (1987),1383. | ||
2. | orl-rat LD50:185 mg/kg | JMCMAR Journal of Medicinal Chemistry. 16 (1973),782. | ||
3. | scu-rat LD50:78,700 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
4. | ivn-rat LD50:7490 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
5. | orl-mus LD50:105 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1633. | ||
6. | ipr-mus LD50:28 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1633. | ||
7. | scu-mus LD50:75 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 24 (1974),1636. | ||
8. | ivn-mus LD50:12,600 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),913. | ||
9. | orl-gpg LD50:41,500 µg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),1204. |