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Memantine

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Name

Memantine

EINECS 690-724-9
CAS No. 19982-08-2 Density 1.046 g/cm3
PSA 26.02000 LogP 4.19640
Solubility N/A Melting Point 153oC
Formula C12H21N Boiling Point 239.8 °C at 760 mmHg
Molecular Weight 179.305 Flash Point 92.3 °C
Transport Information N/A Appearance White powder.
Safety 24/25 Risk Codes N/A
Molecular Structure Molecular Structure of 19982-08-2 (Memantine) Hazard Symbols IrritantXi
Synonyms

1-Adamantanamine,3,5-dimethyl- (8CI);1,3-Dimethyl-5-aminoadamantane;1-Amino-3,5-dimethyladamantane;3,5-Dimethyl-1-adamantylamine;Alzantin;D 145;D 145 (sympathomimetic);DMAA;DRG 0267;Ebixa;

Article Data 46

Memantine Chemical Properties

MF: C12H21N
Density: 1.046 g/cm3
Flash Point: 92.3 °C
MW: 179.301840 g/mol

Product Name: Memantine

IUPAC: 3,5-dimethyladamantan-1-amine
Boiling Point: 239.8 °C at 760 mmHg
Enthalpy of Vaporization: 47.67 kJ/mol
Vapour Pressure: 0.0393 mmHg at 25°C 
Synonyms: AKOS BB-9600 ; MEMANTINE ; AURORA KA-7643 ; TIMTEC-BB SBB002574 ; 3,5-dimethyladamantan-1-amine HCl ; 1-Amino-3,5-dimethyladamantane ; 3,5-Dimethyl-1-aminoadamantane ; 3,5-DIMETHYL-1-AMINOADAMANTANE( MEMANTINE )
Following is the molecular structure of Memantine (19982-08-2):









 

Memantine History

Memantine was first synthesized and patented by Eli Lilly and Company in 1968 (as cited in the Merck Index), and then developed by Merz  in collaboration with Neurobiological Technologies, Inc. and licensed to Forest for the U.S. and Lundbeck for selected European and international markets.

Memantine Uses


Memantine has been associated with a moderate decrease in clinical deterioration in Alzheimer's disease.A systematic review of randomised controlled trials found that memantine has a small positive effect on cognition, mood, behaviour, and the ability to perform daily activities in moderate to severe Alzheimer's disease, but an unknown effect in mild to moderate disease.
Memantine is also being tested for opioid dependence, systemic lupus erythematosus, depression, obsessive compulsive disorder, Tourette Syndrome, problem gambling, attention-deficit hyperactivity disorder (ADHD),glaucoma, tinnitus, neuropathic pain including Complex Regional Pain Syndrome, pervasive developmental disorders, HIV associated dementia, nystagmus, and multiple sclerosis.

Memantine Safety Profile

Safety Information of Memantine (19982-08-2):
Hazard Codes : Xi
Xi : Irritant
Safety Statements  24/25 ( Avoid contact with skin and eyes  )
Hazardous Substances Data: 19982-08-2(Hazardous Substances Data)
 

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