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dehydromequitazine
mequitazine
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 24h; | 91% |
With hydrogen; palladium 10% on activated carbon In methanol; toluene at 20℃; under 75007.5 Torr; for 24h; | 91% |
(E)-10-(1-azabicyclo[2.2.2]oct-3-ylidenemethyl)phenothiazine
mequitazine
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid at 0 - 32℃; for 2.5h; Inert atmosphere; Large scale; | 85% |
With hydrogen; acetic acid; palladium-carbon In methanol; water | |
With hydrogen; acetic acid; palladium-carbon In methanol; water |
10H-phenothiazine
3-chloromethyl-quinuclidine; hydrochloride
tartaric acid
mequitazine
Conditions | Yield |
---|---|
In 5,5-dimethyl-1,3-cyclohexadiene; acetic acid methyl ester; water; ethyl acetate |
mequitazine
Conditions | Yield |
---|---|
With hydrogenchloride In water |
mequitazine
10-(1-azabicyclo[2.2.2]oct-3-yl-methyl)-10H-pheno-thiazine sulfoxide
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite In water at 20℃; |
Conditions | Yield |
---|---|
In acetone for 0.5h; Milling; |
Conditions | Yield |
---|---|
at 180℃; for 6h; |
Conditions | Yield |
---|---|
In acetone for 0.5h; Milling; |
Conditions | Yield |
---|---|
With water for 0.5h; Milling; |
Chemical Name: Mequitazine
IUPAC NAME: 10-(1-Azabicyclo[2.2.2]octan-8-ylmethyl)phenothiazine
CAS No.: 29216-28-2
EINECS: 249-521-7
Molecular Formula: C20H22N2S
Molecular Weight: 322.47 g/mol
Melting Point: 143-145°C
Density: 1.28 g/cm3
Flash Point: 237.7 °C
Boiling Point: 469.4 °C at 760 mmHg
Following is the structure of Mequitazine (29216-28-2):
Product Categories about Mequitazine (29216-28-2) are Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals
The chemical synonymous of Mequitazine (29216-28-2) are 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine ; 10-(3-Quinuclidinylmethyl)phenothiazine ; Butix ; Instotal ; Lm 209 ; Mequitazina ; Metaplexan ; Mircol
Mequitazine (29216-28-2) is used as an antihistamine.
1. | orl-rat LD50:245 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491. | ||
2. | ipr-rat LD50:54 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491. | ||
3. | scu-rat LD50:690 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491. | ||
4. | orl-mus LD50:210 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491. | ||
5. | ipr-mus LD50:54 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491. | ||
6. | scu-mus LD50:278 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 22 (1981),491. |
Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits toxic fumes of SOx and NOx.