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| CAS No.: | 1115-70-4 |
|---|---|
| Name: | 1,1-Dimethylbiguanide hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | C4H12ClN5 |
| Molecular Weight: | 165.626 |
| Synonyms: | Diaformin;Dialon;Diformin;Diformin Retard;Dimefor;Fornidd;Geamet;Glucomin;Glucomine;Gluconil;Glucophage;Glucophage 850;Glucophage Forte;Glucophage Retard;Glucophage SR;Glufor;Gluformin;Glumeformin;Glumetza;Glumin;Glupermin;Glyceriphage;Glyciphage;Glycon;Metomin;Miformin;N,N-Dimethylbiguanide hydrochloride;N,N-Dimethylbiguanidinium chloride;N1,N1-Dimethylbiguanide hydrochloride;Orabet;Siamformet;Walaphage;Biguanide, 1,1-dimethyl-, monohydrochloride(8CI);Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride (9CI);1,1-Dimethylbiguanide hydrochloride; |
| EINECS: | 214-230-6 |
| Density: | 1.36[at 20℃] |
| Melting Point: | 223-226 °C(lit.) |
| Boiling Point: | 224.1 °C at 760 mmHg |
| Flash Point: | 89.3 °C |
| Solubility: | Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM). |
| Appearance: | crystalline solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/38 |
| Safety: | 26-36 |
| PSA: | 88.99000 |
| LogP: | 1.05850 |
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Specification
1. Introduction of Metformin hydrochloride
Metformin hydrochloride is one kind of crystalline solid or white powder. The IUPAC Name of this chemical is 3-(Diaminomethylidene)-1,1-dimethylguanidine hydrochloride. Besides, Metformin hydrochloride belongs to Intermediates & Fine Chemicals; Pharmaceuticals; API's; Miscellaneous Compounds. In addition, Metformin hydrochloride Classification Code is Antidiabetic; Drug / Therapeutic Agent; Skin / Eye Irritant. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether and chloroform.
2. Properties of Metformin hydrochloride
Physical properties about Metformin hydrochloride are:
(1)Molecular Weight: 165.62; (2)H bond acceptors: 5; (3)H bond donors: 5; (4)Freely Rotating Bonds: 1; (5)Polar Surface Area: 34.44 Å2; (6)Merck: 13,5963; (7)Flash Point: 89.3 °C; (8)Enthalpy of Vaporization: 46.06 kJ/mol; (9)Boiling Point: 224.1 °C at 760 mmHg; (10)Vapour Pressure: 0.0929 mmHg at 25°C; (11)Melting point: 223-226 °C; (12)Appearance: Crystalline Solid; (13)Prisms from water, mp 232 deg C; (14)Crystals from propanol, mp 218-220 deg C; (15)H-Bond Donor: 4; (16)H-Bond Acceptor: 1.
3. Structure Descriptors of Metformin hydrochloride
(1)InChI: InChI=1/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
(2)Smiles: C(NC(N)=N)(N(C)C)=N.Cl
(3)Canonical SMILES : CN(C)C(=N)N=C(N)N.Cl
(4)InChIKey: OETHQSJEHLVLGH-UHFFFAOYSA-N
4. Toxicity of Metformin hydrochloride
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intramuscular | 200mg/kg (200mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960. | |
| guinea pig | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960. | |
| guinea pig | LD50 | oral | 500mg/kg (500mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
| guinea pig | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
| mouse | LD50 | intraperitoneal | 420mg/kg (420mg/kg) | Drugs in Japan Vol. 6, Pg. 841, 1982. | |
| mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04012, | |
| mouse | LD50 | oral | 1450mg/kg (1450mg/kg) | Drugs in Japan Vol. 6, Pg. 841, 1982. | |
| mouse | LD50 | subcutaneous | 225mg/kg (225mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
| rabbit | LD50 | oral | 350mg/kg (350mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
| rabbit | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
| rat | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | French Demande Patent Document. Vol. #2220256, | |
| rat | LD50 | oral | 1gm/kg (1000mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989. | |
| rat | LD50 | subcutaneous | 300mg/kg (300mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989. |
5. Safety information of Metformin hydrochloride
Hazard Codes:
XnRisk Statements: 22-36/38
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DU1800000
6. Uses of Metformin hydrochloride
Metformin hydrochloride is an oral hypoglycemic agent. It can lower plasma glucose levels and improves insulin sensitivity. Metformin hydrochloride Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.
7. Production of Metformin hydrochloride
Metformin hydrochloride (CAS NO.1115-70-4) is derived by Dimethylamine salt reacting with Dicyandiamide.