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Cas Database |
| Name |
Methyl 6-chloro-2-pyridinecarboxylate |
EINECS | -0 |
| CAS No. | 6636-55-1 | Density | 1.295g/cm3 |
| PSA | 39.19000 | LogP | 1.52160 |
| Solubility | Slightly soluble in water. | Melting Point |
93-94oC |
| Formula | C7H6ClNO2 | Boiling Point | 275.832oC at 760 mmHg |
| Molecular Weight | 171.583 | Flash Point | 120.619oC |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Picolinicacid, 6-chloro-, methyl ester (6CI,8CI);6-Chloropyridine-2-carboxylic acidmethyl ester;Methyl (6-chloropyridin-2-yl)acetate;Methyl6-chloro-2-pyridinecarboxylate;Methyl 6-chloropicolinate;NSC 51592; |
Article Data | 19 |
Methyl 6-chloro-2-pyridinecarboxylate Synthetic route
| Conditions | Yield |
|---|---|
| With thionyl chloride at 0 - 50℃; for 6.75h; | 100% |
| Stage #1: methanol; 6-chloropicolinic acid With hydrogenchloride for 15h; Heating / reflux; Stage #2: With sodium hydroxide In water | 95% |
| With hydrogenchloride In water at 80℃; for 48h; | |
| With hydrogenchloride In water at 80℃; for 48h; |
| Conditions | Yield |
|---|---|
| With 18-crown-6 ether; potassium carbonate at 90 - 150℃; for 2h; | 83% |
- 2402-78-0
2,6-dichloropyridine
- 67-56-1
methanol
- 201230-82-2
carbon monoxide
A
- 5453-67-8
2,6-bis(methoxycarbonyl)pyridine
B
- 6636-55-1
methyl 6-chloropicolinate
| Conditions | Yield |
|---|---|
| With triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride at 140℃; under 37503 Torr; for 6h; methoxycarbonylation; | A 81% B n/a |
- 30062-34-1
methyl 2-hydroxy-6-pyridinecarboxylate
- 6636-55-1
methyl 6-chloropicolinate
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 110℃; for 14h; | 61% |
- 2459-07-6
methyl pyridine-2-carboxylate
- 1984-23-2
p-nitrophenyl isocyanide
A
- 6636-55-1
methyl 6-chloropicolinate
| Conditions | Yield |
|---|---|
| Stage #1: methyl pyridine-2-carboxylate With fluorine In dichloromethane at -78 - -50℃; Stage #2: p-nitrophenyl isocyanide In dichloromethane at -50 - 0℃; for 4h; | A 40% B 31% C n/a |
| Conditions | Yield |
|---|---|
| With hydrogenchloride | |
| Multi-step reaction with 2 steps 1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C 2: dichloromethane / 1.58 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C 2: 1.5 h / 20 °C View Scheme |
- 626-05-1
2,6-Dibromopyridine
- 67-56-1
methanol
- 124-38-9
carbon dioxide
A
- 5453-67-8
2,6-bis(methoxycarbonyl)pyridine
B
- 6636-55-1
methyl 6-chloropicolinate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; n-butyllithium Yield given. Multistep reaction. Yields of byproduct given; |
- 4684-94-0
6-chloropicolinic acid
- 16045-88-8, 373-57-9
boron trifluoride methanol complex
- 6636-55-1
methyl 6-chloropicolinate
| Conditions | Yield |
|---|---|
| at 110℃; for 0.25h; |
- 38195-81-2
1-oxy-pyridine-2-carboxylic acid methyl ester
A
- 6636-55-1
methyl 6-chloropicolinate
B
- 24484-93-3
4-Chloro-pyridine-2-carboxylic acid methyl ester
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 80℃; for 17h; Yield given. Yields of byproduct given; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: mCPBA / CH2Cl2 / 48 h / Ambient temperature 2: POCl3 / 17 h / 80 °C View Scheme |
Methyl 6-chloro-2-pyridinecarboxylate Chemical Properties
Molecular structure of Methyl 6-chloro-2-pyridinecarboxylate (CAS NO.6636-55-1) is:
Product Name: Methyl 6-chloro-2-pyridinecarboxylate
CAS Registry Number: 6636-55-1
IUPAC Name: methyl 6-chloropyridine-2-carboxylate
Molecular Weight: 171.58104 [g/mol]
Molecular Formula: C7H6ClNO2
XLogP3-AA: 2
H-Bond Donor: 0
H-Bond Acceptor: 3
Melting Point: 93-94°C
Molar Volume: 132.5 cm3
Surface Tension: 44.4 dyne/cm
Density: 1.294 g/cm3
Flash Point: 120.6 °C
Enthalpy of Vaporization: 51.43 kJ/mol
Boiling Point: 275.8 °C at 760 mmHg
Vapour Pressure: 0.00498 mmHg at 25°C
Product Categories: Picolinic acid series
Methyl 6-chloro-2-pyridinecarboxylate Specification
Methyl 6-chloro-2-pyridinecarboxylate , its cas register number is 6636-55-1. It also can be called 2-Pyridinecarboxylicacid, 6-chloro-, methyl ester ; 6-Chloro-2-pyridinecarboxylic acid methyl ester ; 6-Chloropicolinic acid methyl ester .
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