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Name	Methyl L-prolinate hydrochloride	EINECS	218-363-0
CAS No.	2133-40-6	Density	1.055 g/cm³
PSA	38.33000	LogP	1.04220
Solubility	N/A	Melting Point	69-71 °C(lit.)
Formula	C₆H₁₂ClNO₂	Boiling Point	169.9 °C at 760 mmHg
Molecular Weight	165.62	Flash Point	56.5 °C
Transport Information	N/A	Appearance	crystalline
Safety	26-37/39	Risk Codes	36/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	L-Proline,methyl ester, hydrochloride (9CI);Proline, methyl ester, hydrochloride, L-(6CI,7CI,8CI);(2S)-(Methoxycarbonyl)pyrrolidine hydrochloride;(S)-Methylpyrrolidine-2-carboxylate hydrochloride;(S)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride;L-Proline methyl ester monohydrochloride;Methyl proline hydrochloride;H-Pro-OMe.HCl;H-Pro-OMe·HCl;L-Proline, methylester, hydrochloride (1:1);	Article Data	134

Methyl L-prolinate hydrochloride Synthetic route

: 67-56-1
methanol

: 147-85-3
L-proline

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
With thionyl chloride for 1.5h; Heating;	100%
With hydrogenchloride for 4h; Ambient temperature;	100%
With thionyl chloride for 1.5h; Heating;	100%

: 147-85-3
L-proline

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
With thionyl chloride In methanol at 20℃;	100%
With sulfuryl dichloride; trimethyl orthoformate In methanol
With sulfuryl dichloride; trimethyl orthoformate In methanol
With sulfuryl dichloride; trimethyl orthoformate In methanol

: 5211-23-4
N-carbobenzyloxy-L-proline methyl ester

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol; ethyl acetate at 80℃; under 750.075 Torr;	99%

: 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
With aluminium chloride doped on a neutral alumina for 0.0166667h; Irradiation;	88%
With thionyl chloride In methanol at 0 - 75℃; for 1.5h;	86%
With hydrogenchloride In ethyl acetate at 15℃; for 2h;

: 67-56-1
methanol

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
Stage #1: methanol; 1-(tert-butoxycarbonyl)-L-proline With thionyl chloride at 70℃; for 7.5h; Inert atmosphere; Cooling with ice; Stage #2: With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 0.0833333h; Inert atmosphere;	88%
Stage #1: methanol; 1-(tert-butoxycarbonyl)-L-proline With thionyl chloride at 70℃; for 7.5h; Cooling with ice; Stage #2: With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 0.0833333h;	88%

: 67-56-1
methanol

: 147-85-3
L-proline

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
With thionyl chloride Ambient temperature;

: 67-56-1
methanol

: 175446-63-6
proline acid chloride

: 2133-40-6
L-proline methyl ester monohydrochloride

: 147-85-3
L-proline

: 74-88-4
methyl iodide

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
Stage #1: L-proline With thionyl chloride Stage #2: methyl iodide

: 147-85-3
L-proline

3-CH3O-phenyl halide: 3-CH3O-phenyl halide

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 View Scheme

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 2133-40-6
L-proline methyl ester monohydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water

Methyl L-prolinate hydrochloride Chemical Properties

The Molecular Structure of L-Proline methyl ester hydrochloride (CAS NO.2133-40-6):

Empirical Formula: C₆H₁₂ClNO₂
Molecular Weight: 165.618
IUPAC Name: methyl pyrrolidine-2-carboxylate hydrochloride
Appearance: Crystalline
Nominal Mass: 165 Da
Average Mass: 165.618 Da
Monoisotopic Mass: 165.055656 Da
Flash Point: 56.5 °C
Melting Point: 69-71 °C
Enthalpy of Vaporization: 40.63 kJ/mol
Boiling Point: 169.9 °C at 760 mmHg
Vapour Pressure: 1.51 mmHg at 25°C
Synonyms: H-l-pro-ome hcl ; H-pro-ome hcl ; Methyl l-prolinate hydrochloride ; L-pyrrolidine-2-carboxylic acid methyl ester hcl ; L-proline methyl ester hydrochloride ; L-proline methyl ester hydrochloride salt ; Proline-ome hcl ; L-proline methyl ester hcl
Product Categories: AMINOACIDS DERIVATIVES;Esters;Pyrrolidines;Amino Acid Derivatives;Amino Acids;Proline [Pro, P];Amino Acids and Derivatives;Amino hydrochloride;Peptide Synthesis;Amino Acid Derivatives;Proline

Methyl L-prolinate hydrochloride Toxicity Data With Reference

RTECS#: CAS# 2133-40-6 unlisted.
LD₅₀/LC₅₀: Not available.
Carcinogenicity: l-PROLINE methyl ester hydrochloride -Not listed by ACGIH, IARC, or NTP.

Methyl L-prolinate hydrochloride Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/38
R36/38: Irritating to eyes and skin
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
F: 3-8-10-21
Hazard Note: Harmful

Methyl L-prolinate hydrochloride Specification

Conditions to Avoid: Incompatible materials, dust generation, excess HEAT, exposure to moist air or WATER.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Hydrogen chloride, NITROGEN oxides, CARBON monoxide, irritating and toxic fumes and gases, CARBON dioxide.
Hazardous Polymerization: Has not been reported

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