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N-Methyl-N-nitrosoethylcarbamate

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Name

N-Methyl-N-nitrosoethylcarbamate

EINECS N/A
CAS No. 615-53-2 Density 1,14 g/cm3
PSA 58.97000 LogP 0.75610
Solubility 36.99g/L(24 oC) Melting Point N/A
Formula C4H8 N2 O3 Boiling Point 66 °C / 13mmHg
Molecular Weight 132.119 Flash Point 38.6°C
Transport Information N/A Appearance N/A
Safety Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Experimental reproductive effects. Mutation data reported. Has been implicated as a transplacental brain carcinogen. Combustible when exposed to heat, sparks, open flame, and powerful oxidizers. Explodes when heated. A storage hazard. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES and CARBAMATES. Risk Codes N/A
Molecular Structure Molecular Structure of 615-53-2 (N-NITROSO-N-METHYLURETHANE) Hazard Symbols N/A
Synonyms

Carbamicacid, methylnitroso-, ethyl ester (6CI,8CI,9CI); EthylN-methylnitrosocarbamate; Methylnitrosourethane; N-Methyl-N-nitrosourethane;N-Nitroso-N-methylurethane; NMU; NSC 2860; Nitrosomethylurethane

Article Data 7

N-Methyl-N-nitrosoethylcarbamate Chemical Properties

IUPAC Name: Ethyl N-methyl-N-nitrosocarbamate
Synonyms of N-Methyl-N-nitrosoethylcarbamate (CAS NO.615-53-2) : Carbamic acid, N-methyl-N-nitroso-, ethyl ester ; Ethyl methyl(nitroso)carbamate ; Carbamic acid, methylnitroso-, ethyl ester ; Ethyl ester of methylnitroso-carbamic acid
InChI:InChI=1/C4H8N2O3/c1-3-9-4(7)6(2)5-8/h3H2,1-2H3
Product Categories: Analytical Chemistry;Diazomethane Precursors & Equivalents (GC Derivatizing Reagents);Esterification & Alkylation (GC Derivatizing Reagents);GC Derivatizing Reagents
CAS NO:615-53-2
Molecular Formula:C4H8N2O3                                           
Molecular Weight :132.1179                                                           
Molecular Structure :
EINECS: 210-432-3
Surface Tension: 38.6 dyne/cm 
Density: 1.18 g/cm3 
Flash Point: 38.6 °C 
Enthalpy of Vaporization: 37.75 kJ/mol 
Boiling Point: 140.3 °C at 760 mmHg 
Vapour Pressure: 6.18 mmHg at 25°C 
Storage temp: Refrigerator
Form: N-Methyl-N-nitrosoethylcarbamate (CAS NO.615-53-2) is solid.

N-Methyl-N-nitrosoethylcarbamate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LDLo subcutaneous 21mg/kg (21mg/kg)   American Journal of Pathology. Vol. 50, Pg. 639, 1967.
mammal (species unspecified) LD50 intravenous 4mg/kg (4mg/kg)   Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975.
mammal (species unspecified) LD50 oral 240mg/kg (240mg/kg)   Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975.
mouse LCLo inhalation 600mg/m3/10M (600mg/m3)   National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. MAR1942,
mouse LD50 intraperitoneal 37mg/kg (37mg/kg)   Cancer Research. Vol. 30, Pg. 11, 1970.
mouse LDLo subcutaneous 7mg/kg (7mg/kg)   British Journal of Cancer. Vol. 23, Pg. 167, 1969.
rat LD50 intravenous 4mg/kg (4mg/kg)   Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
rat LD50 oral 180mg/kg (180mg/kg)   Naturwissenschaften. Vol. 48, Pg. 165, 1961.
rat LDLo intraperitoneal 50mg/kg (50mg/kg)   British Journal of Cancer. Vol. 22, Pg. 316, 1968.
rat LDLo subcutaneous 125mg/kg (125mg/kg)   British Journal of Cancer. Vol. 16, Pg. 92, 1962.

N-Methyl-N-nitrosoethylcarbamate Consensus Reports

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 4 ,1974,p. 211.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

N-Methyl-N-nitrosoethylcarbamate Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Experimental reproductive effects. Mutation data reported. Has been implicated as a transplacental brain carcinogen. Combustible when exposed to heat, sparks, open flame, and powerful oxidizers. Explodes when heated. A storage hazard. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES and CARBAMATES.

Risk Statements 5-36/37/38-40
R5 : Heating may cause an explosion. 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R40: Limited evidence of a carcinogenic effect.
Safety Statements 23-35-45-53
S23: Do not breathe vapour. 
S35: This material and its container must be disposed of in a safe way. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53: Avoid exposure - obtain special instructions before use.
RIDADR: 2810
RTECS: FC6300000
HazardClass: 1.1A
PackingGroup: I

N-Methyl-N-nitrosoethylcarbamate Specification

1.Reactivity Profile: N-Methyl-N-nitrosoethylcarbamate (CAS NO.615-53-2) is a N-nitrosated carbamate ester. Incompatible with strong acids and bases. Especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen may be produced by the combination with active metals or nitrides Incompatible with oxidizing acids, peroxides, and hydroperoxides.


2.Health Hazard :TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.


3.Fire Hazard :Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

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