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CAS No.: | 615-53-2 |
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Name: | N-NITROSO-N-METHYLURETHANE |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C4H8 N2 O3 |
Molecular Weight: | 132.119 |
Synonyms: | Carbamicacid, methylnitroso-, ethyl ester (6CI,8CI,9CI); EthylN-methylnitrosocarbamate; Methylnitrosourethane; N-Methyl-N-nitrosourethane;N-Nitroso-N-methylurethane; NMU; NSC 2860; Nitrosomethylurethane |
Density: | 1,14 g/cm3 |
Boiling Point: | 66 °C / 13mmHg |
Flash Point: | 38.6°C |
Solubility: | 36.99g/L(24 oC) |
Safety: | Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Experimental reproductive effects. Mutation data reported. Has been implicated as a transplacental brain carcinogen. Combustible when exposed to heat, sparks, open flame, and powerful oxidizers. Explodes when heated. A storage hazard. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES and CARBAMATES. |
PSA: | 58.97000 |
LogP: | 0.75610 |
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IUPAC Name: Ethyl N-methyl-N-nitrosocarbamate
Synonyms of N-Methyl-N-nitrosoethylcarbamate (CAS NO.615-53-2) : Carbamic acid, N-methyl-N-nitroso-, ethyl ester ; Ethyl methyl(nitroso)carbamate ; Carbamic acid, methylnitroso-, ethyl ester ; Ethyl ester of methylnitroso-carbamic acid
InChI:InChI=1/C4H8N2O3/c1-3-9-4(7)6(2)5-8/h3H2,1-2H3
Product Categories: Analytical Chemistry;Diazomethane Precursors & Equivalents (GC Derivatizing Reagents);Esterification & Alkylation (GC Derivatizing Reagents);GC Derivatizing Reagents
CAS NO:615-53-2
Molecular Formula:C4H8N2O3
Molecular Weight :132.1179
Molecular Structure :
EINECS: 210-432-3
Surface Tension: 38.6 dyne/cm
Density: 1.18 g/cm3
Flash Point: 38.6 °C
Enthalpy of Vaporization: 37.75 kJ/mol
Boiling Point: 140.3 °C at 760 mmHg
Vapour Pressure: 6.18 mmHg at 25°C
Storage temp: Refrigerator
Form: N-Methyl-N-nitrosoethylcarbamate (CAS NO.615-53-2) is solid.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
hamster | LDLo | subcutaneous | 21mg/kg (21mg/kg) | American Journal of Pathology. Vol. 50, Pg. 639, 1967. | |
mammal (species unspecified) | LD50 | intravenous | 4mg/kg (4mg/kg) | Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975. | |
mammal (species unspecified) | LD50 | oral | 240mg/kg (240mg/kg) | Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975. | |
mouse | LCLo | inhalation | 600mg/m3/10M (600mg/m3) | National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. MAR1942, | |
mouse | LD50 | intraperitoneal | 37mg/kg (37mg/kg) | Cancer Research. Vol. 30, Pg. 11, 1970. | |
mouse | LDLo | subcutaneous | 7mg/kg (7mg/kg) | British Journal of Cancer. Vol. 23, Pg. 167, 1969. | |
rat | LD50 | intravenous | 4mg/kg (4mg/kg) | Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967. | |
rat | LD50 | oral | 180mg/kg (180mg/kg) | Naturwissenschaften. Vol. 48, Pg. 165, 1961. | |
rat | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | British Journal of Cancer. Vol. 22, Pg. 316, 1968. | |
rat | LDLo | subcutaneous | 125mg/kg (125mg/kg) | British Journal of Cancer. Vol. 16, Pg. 92, 1962. |
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 4 ,1974,p. 211.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Experimental reproductive effects. Mutation data reported. Has been implicated as a transplacental brain carcinogen. Combustible when exposed to heat, sparks, open flame, and powerful oxidizers. Explodes when heated. A storage hazard. When heated to decomposition it emits toxic fumes of NOx. See also NITROSAMINES and CARBAMATES.
Risk Statements 5-36/37/38-40
R5 : Heating may cause an explosion.
R36/37/38: Irritating to eyes, respiratory system and skin.
R40: Limited evidence of a carcinogenic effect.
Safety Statements 23-35-45-53
S23: Do not breathe vapour.
S35: This material and its container must be disposed of in a safe way.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
RIDADR: 2810
RTECS: FC6300000
HazardClass: 1.1A
PackingGroup: I
1.Reactivity Profile: N-Methyl-N-nitrosoethylcarbamate (CAS NO.615-53-2) is a N-nitrosated carbamate ester. Incompatible with strong acids and bases. Especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen may be produced by the combination with active metals or nitrides Incompatible with oxidizing acids, peroxides, and hydroperoxides.
2.Health Hazard :TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
3.Fire Hazard :Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.