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Nabumetone
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Name

Nabumetone

 EINECS N/A
CAS No. 42924-53-8 Density 1.084 g/cm3
PSA 26.30000 LogP 3.37000
Solubility 6mg/L(22.5 oC) Melting Point 80-81 °C
Formula C15H16O2 Boiling Point 371.1 °C at 760 mmHg
Molecular Weight 228.291 Flash Point 165.4 °C
Transport Information N/A Appearance White powder
Safety 36/37 Risk Codes 22-40
Molecular Structure Molecular Structure of 42924-53-8 (Nabumetone) Hazard Symbols HarmfulXn
Synonyms

1-(2'-Methoxynaphth-6'-yl)butan-3-one;4-(6-Methoxy-2-naphthyl)-2-butanone;Arthaxan;BRL 14777;Balmox;Consolan;Gambaran;Nabugesic 500;Nabumeton;Nabuser;Relafen;Relifen;Relifex;

Article Data 32

Nabumetone Synthetic route

127053-22-9, 56600-90-9

4-(2-methoxynaphthalene-6-yl)but-3-en-2-one

42924-53-8

nabumetone

Conditions
ConditionsYield
With hydrogen In toluene at 50℃; under 3750.38 Torr; for 1h; Catalytic behavior; Temperature; Pressure; Inert atmosphere; Schlenk technique; Autoclave;99%
With 1% Pd on activated carbon; hydrogen In water at 45℃; under 760.051 Torr; for 15h; Reagent/catalyst; Green chemistry; chemoselective reaction;95%
With hydrogen In N,N-dimethyl-formamide at 100℃;90%
78-94-4

methyl vinyl ketone

tris(6-methoxy-2-naphthyl)stibine

42924-53-8

nabumetone

Conditions
ConditionsYield
With palladium diacetate; silver(I) acetate; acetic acid at 25℃; for 24h;99%
73356-31-7

4-(6-methoxy-2-naphthalenyl)-4-hydroxybut-3-en-2-one

42924-53-8

nabumetone

Conditions
ConditionsYield
palladium on charcoal catalyst In acetic acid93%
Multi-step reaction with 3 steps
1: acetic acid; hydrogen; palladium on activated charcoal / 20 °C
2: sulfuric acid
3: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: hydrogen; palladium 10% on activated carbon; sulfuric acid / ethyl acetate
2: sulfuric acid
3: hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
3453-33-6

6-methoxynaphthalene-2-carbaldehyde

67-64-1

acetone

A

C18H22O2

B

42924-53-8

nabumetone

Conditions
ConditionsYield
With hydrogen; Pd/Mg-Al hydrotalcite at 74.84℃; under 3750.38 Torr; for 1.25h;A 11 % Chromat.
B 89%
5111-65-9

2-Bromo-6-methoxynaphthalene

78-94-4

methyl vinyl ketone

42924-53-8

nabumetone

Conditions
ConditionsYield
With tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; nickel dibromide In pyridine; N,N-dimethyl-formamide at 70℃; Electrochemical reaction;85%
Stage #1: methyl vinyl ketone With [2,2]bipyridinyl; water; cobalt(II) bromide In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 2-Bromo-6-methoxynaphthalene With pyridine; trifluoroacetic acid; lithium bromide; zinc In N,N-dimethyl-formamide at 80℃; for 0.333333h;		50%
598-32-3

2-hydroxy-3-butene

5111-65-9

2-Bromo-6-methoxynaphthalene

A

42924-53-8

nabumetone

B

127053-21-8

4-(6-methoxy-2-naphthyl)-3-butene-2-ol

Conditions
ConditionsYield
Stage #1: 2-hydroxy-3-butene With dicyclohexylmethylamine; tetrabutylammomium bromide In N,N-dimethyl acetamide; water at 20℃; for 0.25h; Heck reaction;
Stage #2: 2-Bromo-6-methoxynaphthalene; 4'-hydroxyacetophenone oxime palladacycle catalyst In N,N-dimethyl acetamide; water at 120℃; for 9h; Heck reaction; Further stages.;		A 82%
B n/a
With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride In various solvent(s) at 140℃; for 5h; Yield given;A n/a
B 9%

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

42924-53-8

nabumetone

Conditions
ConditionsYield
With sodium hydroxide; sodium acetate; sodium acetate trihydrate; palladium In methanol; water; hydrogen; toluene79.7%
With sodium hydroxide; sodium acetate; sodium acetate trihydrate; palladium In methanol; water; hydrogen; toluene79.7%

sodium metabisulfite

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

42924-53-8

nabumetone

Conditions
ConditionsYield
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene78.5%
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene78.5%
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene74.8%
With sodium hydroxide; sodium acetate; palladium In water; hydrogen; isopropyl alcohol; toluene74.8%
598-32-3

2-hydroxy-3-butene

5111-65-9

2-Bromo-6-methoxynaphthalene

42924-53-8

nabumetone

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium formate; sodium hydrogencarbonate; Pd-benzothiazole carbene at 130℃; for 3h; Heck reaction;75%
With tetrabutylammomium bromide; sodium hydrogencarbonate; palladium dichloride at 120℃; for 6h; Heck coupling;74%
Stage #1: 2-hydroxy-3-butene With dicyclohexylmethylamine; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 0.25h; Heck reaction;
Stage #2: 2-Bromo-6-methoxynaphthalene; 4'-hydroxyacetophenone oxime palladacycle catalyst In N,N-dimethyl acetamide at 120℃; for 24h; Heck reaction; Further stages.;		90 % Spectr.
With Fe3O4@chitosan nanoparticles/Pd In ethanol at 140℃; for 24h;
3453-33-6

6-methoxynaphthalene-2-carbaldehyde

67-64-1

acetone

42924-53-8

nabumetone

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; carbon monoxide In neat (no solvent) at 200℃; for 72h; Temperature; Autoclave;75%
With hydrogen; magnesium oxide; palladium at 59.84℃; under 3750.38 Torr; for 1h;98 % Chromat.

Nabumetone Specification

The IUPAC name of this chemical is 4-(6-methoxynaphthalen-2-yl)butan-2-one. With the CAS registry number 42924-53-8, it is also named as Nabumetone. The product's categories are Active Pharmaceutical Ingredients; Anti-Inflammatory; Analgesic; Intermediates & Fine Chemicals; Pharmaceuticals; Steroids. It is white powder which is a non-steroidal anti-inflammatory drug (NSAID), the only 1-naphthaleneacetic acid derivative. When heated to decomposition it emits acrid smoke and irritating fumes.

The other characteristics of 4-(6-Methoxy-2-naphthyl)-2-butanone can be summarized as: (1)ACD/LogP: 2.82; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.82; (4)ACD/LogD (pH 7.4): 2.82; (5)ACD/BCF (pH 5.5): 81.48; (6)ACD/BCF (pH 7.4): 81.48; (7)ACD/KOC (pH 5.5): 811.97; (8)ACD/KOC (pH 7.4): 811.97; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.575; (13)Molar Refractivity: 69.61 cm3; (14)Molar Volume: 210.5 cm3; (15)Polarizability: 27.59×10-24 cm3; (16)Surface Tension: 39.8 dyne/cm; (17)Enthalpy of Vaporization: 61.8 kJ/mol; (18)Vapour Pressure: 1.06E-05 mmHg at 25°C; (19)Rotatable Bond Count: 4; (20)Tautomer Count: 3; (21)Exact Mass: 228.11503; (22)MonoIsotopic Mass: 228.11503; (23)Topological Polar Surface Area: 26.3; (24)Heavy Atom Count: 17; (25)Complexity: 262. 

Preparation of 4-(6-Methoxy-2-naphthyl)-2-butanone: It can be obtained by but-3-en-2-one and tris-(6-methoxy-naphthalen-2-yl)-stibane. This reaction needs reagents Pd(OAc)2, AgOAc and AcOH at temperature of 25 °C. The reaction time is 24 hours. The yield is 99%.

Uses of 4-(6-Methoxy-2-naphthyl)-2-butanone: It is used to treat pain or inflammation caused by arthritis. And it works by reducing the effects of hormones that cause pain and inflammation. In addition, it can react with thiazolidine-2,4-dione to get 5-[3-(6-methoxy-naphthalen-2-yl)-1-methyl-propylidene]-thiazolidine-2,4-dione. This reaction needs reagent benzoic acid, piperidine and solvent toluene by heating. The yield is 80%.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. And it has limited evidence of a carcinogenic effect. If you want to contact this product, you must wear suitable protective clothing and gloves. 

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(C)CCc1ccc2c(c1)ccc(OC)c2
2. InChI:InChI=1/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3 
3. InChIKey:BLXXJMDCKKHMKV-UHFFFAOYAR

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 oral 3200mg/kg (3200mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988.
mouse LD50 intraperitoneal 2380mg/kg (2380mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH		 Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988.
mouse LD50 oral 4290mg/kg (4290mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: OTHER CHANGES		 Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988.
rat LD50 intraperitoneal 1520mg/kg (1520mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988.
rat LD50 oral 3880mg/kg (3880mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: OTHER CHANGES		 Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988.
women TDLo oral 1260mg/kg/6W- (1260mg/kg) LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)

LUNGS, THORAX, OR RESPIRATION: COUGH

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Postgraduate Medical Journal. Vol. 67, Pg. 1021, 1991.
 

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