The l-Naloxone with CAS registry number of 465-65-6 is also known as N-Allyl-noroxymorphone. The systematic name is (5α)-3,14-Dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one. It belongs to classification codes of Central Nervous System Agents; Drug / Therapeutic Agent; Mutation data; Narcotic antagonists; Peripheral Nervous System Agents; Reproductive Effect; Sensory System Agents. Its EINECS registry number is 207-365-7. In addition, the formula is C₁₉H₂₁NO₄ and the molecular weight is 327.37.

Physical properties about l-Naloxone are: (1)ACD/LogP: 1.45; (2)ACD/LogD (pH 5.5): 0.1; (3)ACD/LogD (pH 7.4): 1.34; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 5.74; (6)ACD/KOC (pH 5.5): 6.61; (7)ACD/KOC (pH 7.4): 112.91; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.691; (12)Molar Refractivity: 87.31 cm³; (13)Molar Volume: 228.1 cm³; (14)Surface Tension: 72 dyne/cm; (15)Density: 1.43 g/cm³; (16)Flash Point: 276.1 °C; (17)Enthalpy of Vaporization: 85.12 kJ/mol; (18)Boiling Point: 532.8 °C at 760 mmHg; (19)Vapour Pressure: 3.49E-12 mmHg at 25 °C.

Preparation of l-Naloxone: it is prepared by reaction of naloxone. The reaction needs reagents DL-methionine, MeSO₃H at the temperature of 40 °C for 15 hours. The yield is about 60%.

Uses of l-Naloxone: it is a drug used to counter the effects of opiate overdose. What's more, it is specifically used to counteract life-threatening depression of the central nervous system and respiratory system. Besides, it can be used to produce 3,14-diacetoxy-17-allyl-4,5a-epoxy-morphinan-6-one by reaction with acetic acid anhydride. The reaction occurs with condition of heating for 1 hour. The yield is about 91%.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O
2. Isomeric SMILES: C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O
3. InChI: InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
4. InChIKey: UZHSEJADLWPNLE-GRGSLBFTSA-N

The toxicity data is as follows: