- Nefazodone
- Nefazodone hydrochloride
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Cas Database |
| Name |
Nefazodone |
EINECS | N/A |
| CAS No. | 83366-66-9 | Density | 1.23±0.1 g/cm3(Predicted) |
| PSA | 55.53000 | LogP | 3.55480 |
| Solubility | Slightly soluble Melting Point |
186 - 188 C |
|
| Formula | C25H32 Cl N5 O2 | Boiling Point | 599.6±60.0 °C(Predicted) |
| Molecular Weight | 470.014 | Flash Point | N/A |
| Transport Information | N/A | Appearance | White to off-white crystalline powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | UN NO. |
| Synonyms |
Nefazodone |
Article Data | 1 |
Nefazodone Chemical Properties
Molecular Formula: C25H32ClN5O2
Molecular Weight: 470.01
Index of Refraction: 1.616
Density: 1.23 g/cm3
Flash Point: 316.4 °C
Melting Point: 180-182°C
Appearance: white solid
Solubility: DMSO: ~11 mg/mL at 60 °C
Enthalpy of Vaporization: 89.26 kJ/mol
Boiling Point: 599.6 °C at 760 mmHg
Vapour Pressure: 2.46E-14 mmHg at 25°C
IUPAC Name: 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
Synonyms: 3H-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy;l)-5-ethyl-4-(2-phenoxyethyl)- ; BMY-13754 ; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride ; Serzone ; MJ-13754-1 ; Nefazodone ; Nefazodone base
Following is the molecular structure of Nefazodone hydrochloride (83366-66-9):
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Nefazodone Toxicity Data With Reference
The toxicity of Nefazodone hydrochloride (83366-66-9):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 40mg/kg/2W-I (40mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS | Journal of Clinical Psychiatry. Vol. 61, Pg. 216, 2000. |
| women | TDLo | oral | 28mg/kg/1W-I (28mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: EXCITEMENT BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING | American Journal of Psychiatry. Vol. 154, Pg. 578, 1997. |
Nefazodone Safety Profile
Safety Information of Nefazodone hydrochloride (83366-66-9):
Safety Statements: 22-24/25
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
WGK Germany: 3
Nefazodone Specification
Side effects of Nefazodone hydrochloride (83366-66-9): Unlike most serotonin reuptake inhibitors, Nefazodone usually has no negative effects on libido or sexual functioning, and is actually sometimes used as an antidote to SSRI or SNRI induced impotence and anorgasmia in men. More serious side effects include an allergic reaction, fainting, or painful/prolonged erection. Less serious reactions of nefazodone include dizziness, lightheadedness, fatigue, upset stomach, insomnia; dry mouth; constipation; or blurred/abnormal vision.
Advantages of Nefazodone hydrochloride (83366-66-9): Nefazodone, though an antidepressant, may also be beneficial in the prophylaxis of migraines due to its antagonistic effects on the 5-HT2A and 5-HT2C receptors It has a more favorable side effect profile than amitriptyline, a tricyclic antidepressant commonly used for migraine prophylaxis.
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