Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Neomycin A	EINECS	N/A
CAS No.	3947-65-7	Density	1.51g/cm³
PSA	203.46000	LogP	-2.31440
Solubility	N/A	Melting Point	225.5°C (rough estimate)
Formula	C12H26 N4 O6	Boiling Point	577.9°C at 760 mmHg
Molecular Weight	322.362	Flash Point	303.3°C
Transport Information	N/A	Appearance	N/A
Safety	Poison by intravenous route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NO_x.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	NeomycinA (6CI,7CI,8CI); (+)-Neamine; Dekamycin V; Neamin; Neamine; Nebramycin X; Negamicin;O-2,6-Diamino-2,6-dideoxy-a-D-glucopyranosyl-(1®4)-1,3-diamino-1,2,3-trideoxy-D-myo-inositol; ST 7	Article Data	20

Neomycin A Synthetic route

: 549501-35-1
(1S,2R,3R,4S,6R)-4,6-Diamino-3-((2R,3R,4R,5R,6R)-3-amino-6-aminomethyl-4,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-cyclohexane-1,2-diol

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
With hydrogen; 20% palladium hydroxide on carbon In water; acetic acid	91%
With hydrogen; acetic acid; palladium dihydroxide

: 119-04-0
neomycin B

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 6h; Heating;	82%
With hydrogenchloride In methanol for 4h; Reflux;	80%
Stage #1: neomycin B With hydrogenchloride; methanol for 16h; acidic methanolysis; Stage #2: With Amberlite IRA-400 (OH-) In methanol for 0.5h; Hydrolysis;	67%
With water Acidic conditions; Inert atmosphere;

: neomycin B trisulfate

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
Stage #1: neomycin B trisulfate With hydrogenchloride In methanol for 6h; Heating; Stage #2: With ammonium hydroxide; ammonia In methanol Further stages.;	70%

: 4146-30-9, 25389-98-4, 28002-70-2, 34289-38-8, 92283-95-9
neomycin B trisulfate

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 80℃; for 3h; pH=< 1;	67%

: 25389-98-4
neomycin B sulphate

A: 98-01-1
furfural

B: 36468-53-8
β-D-ribofuranose

C: 3947-65-7
neomycin A

D: 59433-00-0
2,6-dideoxy-2,6-diamino-D-glucose

E: (2R,3S,4R,5R,6R)-5-Amino-2-aminomethyl-6-((2R,3S,4R,5R)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-furan-3-yloxy)-tetrahydro-pyran-3,4-diol

Conditions

Conditions	Yield
Product distribution; Rate constant; Irradiation; multistep reaction, radiolytic degradation;

...Expand

: 25389-98-4
neomycin B sulphate

A: 98-01-1
furfural

B: 36468-53-8
β-D-ribofuranose

C: 3947-65-7
neomycin A

D: (2S,3R,4R,5S,6S)-3-Amino-6-aminomethyl-tetrahydro-pyran-2,4,5-triol

E: (2S,3S,4R,5R,6R)-5-Amino-2-aminomethyl-6-((2R,3S,4R,5R)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-furan-3-yloxy)-tetrahydro-pyran-3,4-diol

Conditions

Conditions	Yield
Product distribution; Rate constant; Irradiation; multistep reaction, radiolytic degradation;

...Expand

neomycin-B: neomycin-B

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
With hydrogenchloride; methanol
With hydrogenchloride

: 171032-74-9
1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-D-glucopyranose

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: 90 percent / ZnI2 / 1,2-dichloro-ethane / 50 °C 2: 98 percent / NaOMe / methanol 3: 94 percent / pyridine 4: 100 percent / NaN3 / dimethylformamide / 80 °C 5: 86 percent / NaH / dimethylformamide 6: N-iodosuccinimide; silver trifluoromethanesulfonate / diethyl ether; CH2Cl2 / -20 °C 7: NaOMe / methanol 8: P(CH3)3; 0.1 N aq. NaOH / tetrahydrofuran 9: H2; aq. AcOH / 20 percent Pd(OH)2/C View Scheme

Yield

Multi-step reaction with 9 steps
1: 90 percent / ZnI2 / 1,2-dichloro-ethane / 50 °C
2: 98 percent / NaOMe / methanol
3: 94 percent / pyridine
4: 100 percent / NaN3 / dimethylformamide / 80 °C
5: 86 percent / NaH / dimethylformamide
6: N-iodosuccinimide; silver trifluoromethanesulfonate / diethyl ether; CH2Cl2 / -20 °C
7: NaOMe / methanol
8: P(CH3)3; 0.1 N aq. NaOH / tetrahydrofuran
9: H2; aq. AcOH / 20 percent Pd(OH)2/C
View Scheme

: 202462-37-1
phenyl 2-azido-2-deoxy-1-thio-α/β-D-glucopyranoside

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 94 percent / pyridine 2: 100 percent / NaN3 / dimethylformamide / 80 °C 3: 86 percent / NaH / dimethylformamide 4: N-iodosuccinimide; silver trifluoromethanesulfonate / diethyl ether; CH2Cl2 / -20 °C 5: NaOMe / methanol 6: P(CH3)3; 0.1 N aq. NaOH / tetrahydrofuran 7: H2; aq. AcOH / 20 percent Pd(OH)2/C View Scheme

: 183875-22-1
phenyl 2-azido-2-deoxy-3,4,6-tri-O-acetyl-1-thio-α/β-D-glucopyranoside

: 3947-65-7
neomycin A

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: 98 percent / NaOMe / methanol 2: 94 percent / pyridine 3: 100 percent / NaN3 / dimethylformamide / 80 °C 4: 86 percent / NaH / dimethylformamide 5: N-iodosuccinimide; silver trifluoromethanesulfonate / diethyl ether; CH2Cl2 / -20 °C 6: NaOMe / methanol 7: P(CH3)3; 0.1 N aq. NaOH / tetrahydrofuran 8: H2; aq. AcOH / 20 percent Pd(OH)2/C View Scheme

Neomycin A Chemical Properties

Product Name: Neomycin A
CAS: 3947-65-7
The Molecular formula of Neomycin A (CAS NO.3947-65-7): C₁₂H₂₆N₄O₆
The Molecular Weight of Neomycin A (CAS NO.3947-65-7): 322.36
The Molecular Structure of Neomycin A (CAS NO.3947-65-7):

Density: 1.51 g/cm³
Flash Point: 303.3 °C
Boiling Point: 577.9 °C at 760 mmHg
Index of Refraction: 1.649
Molar Refractivity: 77.41 cm³
Molar Volume: 212.4 cm³
Polarizability: 30.69×10^-24cm³
Surface Tension: 92.6 dyne/cm
Enthalpy of Vaporization: 99.33 kJ/mol
Vapour Pressure: 9.19E-16 mmHg at 25°C
Water Solubility: 1e+006(mg/L)at 25°C

Neomycin A History

Neomycin was discovered in 1949 by the microbiologist Selman Waksman and his student Hubert Lechevalier at Rutgers University. It is produced naturally by the bacterium Streptomyces fradiae

Neomycin A Toxicity Data With Reference

1.	scu-mus LD50:1250 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 1 (1978),664.
2.	ivn-mus LD50:320 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 1 (1978),664.
3.	ivn-mus LD50:125 mg/kg	JANTAJ Journal of Antibiotics. 27 (1974),677.

Neomycin A Safety Profile

Poison by intravenous route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NO_x.

Neomycin A Specification

Neomycin A with CAS number of 3947-65-7 is also called for 2-Desoxy-4-O-(2,6-diamino-2,6-didesoxy-alpha-D-glucopyranosyl)-D-streptamin ; 4-18-00-07474 (Beilstein Handbook Reference) ; 4-O-(2,6-Diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine ; BRN 0026714 ; Dekamycin V ; Neamin ; Neamine ; Nebramycin X ; Negamicin ; UNII-5981U00LY0 . Neomycin is overwhelmingly used as a topical preparation, such as Neosporin. It can also be given orally, where it is usually combined with other antibiotics. Neomycin is not absorbed from the gastrointestinal tract, and has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. By killing bacteria in the intestinal tract, it keeps ammonia levels low and prevents hepatic encephalopathy, especially prior to GI surgery. It has also been used to treat small intestinal bacterial overgrowth. It is not given intravenously, as neomycin is extremely nephrotoxic (causes kidney damage), especially compared to other aminoglycosides. The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 0.025 mg per dose.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 3947-65-7