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Cas Database |
| Name |
Niridazole |
EINECS | N/A |
| CAS No. | 61-57-4 | Density | 1.549g/cm3 |
| PSA | 119.29000 | LogP | 1.49790 |
| Solubility | 0.13g/L(25 oC) | Melting Point |
260-262° |
| Formula | C6H6 N4 O3 S | Boiling Point | 278.6°C at 760 mmHg |
| Molecular Weight | 214.205 | Flash Point | 122.3°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Used as an amoebicide and schistosomicidal agent. When heated to decomposition it emits very toxic fumes of SOx and NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1-(5-Nitro-1,3-thiazol-2-yl)-2-imidazolidinone;1-(5-Nitro-2-thiazolyl)-2-imidazolidinone; 1-(5-Nitro-2-thiazolyl)-2-imidazolinone;1-(5-Nitro-2-thiazolyl)-2-oxotetrahydroimidazole; Ambilhar; Ba 32644; Ciba32644; Ciba 32644Ba; NSC 136947; Niridazole; Nitrothiamidazol;Nitrothiamidazole; Nitrothiazol; Nitrothiazole |
Article Data | 13 |
Niridazole Chemical Properties
Product Name: Niridazole (CAS NO.61-57-4)
Molecular Formula: C6H6N4O3S
Molecular Weight: 214.22g/mol
Mol File: 61-57-4.mol
EINECS: 200-512-6
Density: 1.634 g/cm3
Surface Tension: 79.7 dyne/cm
XLogP3-AA: 0.9
H-Bond Donor: 1
H-Bond Acceptor: 4
Structure Descriptors of Niridazole (CAS NO.61-57-4):
IUPAC Name: 1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
Canonical SMILES: C1CN(C(=O)N1)C2=NC=C(S2)[N+](=O)[O-]
InChI: InChI=1S/C6H6N4O3S/c11-5-7-1-2-9(5)6-8-3-4(14-6)10(12)13/h3H,1-2H2,(H,7,11)
InChIKey: RDXLYGJSWZYTFJ-UHFFFAOYSA-N
Niridazole Uses
Niridazole (CAS NO.61-57-4) is used for a treatment of schistosomiasis, the helmintic invasy which caused by a flatworm (thrematod) named schistosoma (old name - bilharzia). It has recently also been investigated for use in the treatment of periodontitis.
Niridazole Toxicity Data With Reference
| 1. | mma-sat 33 ng/plate | ENMUDM Environmental Mutagenesis. 7 (1985),429. | ||
| 2. | bfa-hmn/sat 25 mg/kg | CMMUAO Chemical Mutagens. Principles and Methods for Their Detection 4 (1976),171. | ||
| 3. | orl-mus TDLo:175 mg/kg (male 5D pre):REP | JRPFA4 Journal of Reproduction and Fertility. 46 (1976),217. | ||
| 4. | orl-rat TDLo:8 g/kg/90W-I:NEO | CALEDQ Cancer Letters (Shannon, Ireland). 4 (1978),305. | ||
| 5. | orl-mus TDLo:15 g/kg/49W-C:CAR | CALEDQ Cancer Letters (Shannon, Ireland). 1 (1975),69. | ||
| 6. | orl-mus TD:16 g/kg/75W-C:CAR | JNCIAM Journal of the National Cancer Institute. 59 (1977),1625. | ||
| 7. | orl-rat LD50:900 mg/kg | FAZMAE Fortschritte der Arzneimittelforschung. 17 (1973),108. | ||
| 8. | orl-mus LD50:2500 mg/kg | YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. 15 (1980),456. | ||
| 9. | ipr-mus LD50:220 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 228 (1984),662. |
Niridazole Consensus Reports
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 ,1977,p. 123.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Niridazole Safety Profile
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Used as an amoebicide and schistosomicidal agent. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Niridazole Specification
Niridazole , its CAS NO. is 61-57-4, the synonyms are 2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)- ; 1-(5-Nitro-2-thiazolyl)-2-imidazolidinone ; 1-(5-Nitro-2-thiazolyl)-2-imidazolinone ; 1-(5-Nitro-2-thiazolyl)-2-oxotetrahydroimidazole ; AI3-51833 ; Ambilhar ; BA 32644 Ciba ; BRN 0665338 ; CCRIS 434 ; Ciba 32644-Ba ; EINECS 200-512-6 ; HSDB 7480 ; NSC 136947 ; Nitrothiamidazole ; UNII-N116U8Y5QQ .
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