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Name	Nitrazepam	EINECS	205-665-2
CAS No.	146-22-5	Density	1.4 g/cm³
PSA	87.28000	LogP	2.48110
Solubility	76.9 mg/L 25 °C in water	Melting Point	226-229 ºC
Formula	C₁₅H₁₁N₃O₃	Boiling Point	497 ºC at 760 mmHg
Molecular Weight	281.271	Flash Point	254.4 ºC
Transport Information	N/A	Appearance	Pink Solid
Safety	Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NO_x. See also DIAZEPAM.	Risk Codes	R22
Molecular Structure		Hazard Symbols
Synonyms	1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepine-2-one;7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;Benzalin;Calsmin;Dormicum;Dormicum (anticonvulsant);Dormin 5;Eatan;Epibenzalin;Epinelbon;Eunoctin;Hipnax;Hipsal;Imeson;Insomin;Ipersed;LA 1;Megadon;Mogadan;Mogadon;Mogadone;N-Desmethylnimetazepam;NSC 58775;Nelbon;Neozepam;Neuchlonic;Nipam;Nitrados;Nitravet;Nitrazepam;Nitrenpax;Nitrosun;Noctesed;Paxisyn;Pelson;Radedorm;Relact;Remnos;Ro 4-5360;Ro 5-3059;Somitran;Somnased;Somnibel;Somnite;Sonebon;Sonnolin;Surem;Unisomnia;Xiaoxipan;2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-nitro-5-phenyl-;	Article Data	56

Nitrazepam Chemical Properties

Molecular Structure of 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5):

IUPAC Name: 7-Nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Canonical SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3
InChI: InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)
InChIKey: KJONHKAYOJNZEC-UHFFFAOYSA-N
Molecular Weight: 281.26614 [g/mol]
Molecular Formula: C₁₅H₁₁N₃O₃
XLogP3: 2.2
H-Bond Donor: 1
H-Bond Acceptor: 4
EINECS: 205-665-2
Index of Refraction: 1.689
Molar Refractivity: 76.64 cm³
Molar Volume: 200.6 cm³
Surface Tension: 60.6 dyne/cm
Density: 1.4 g/cm³
Flash Point: 254.4 °C
Enthalpy of Vaporization: 76.49 kJ/mol
Boiling Point: 497 °C at 760 mmHg
Vapour Pressure: 5.15E-10 mmHg at 25 °C
Appearance: Pink Solid
Melting Point: 225 °C
Water Solubility: 76.9 mg/L 25 °C
Classification Code: Anti-Anxiety Agents; Anticonvulsant; Anticonvulsants; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; GABA Agents; GABA modulators; Hypnotics and Sedatives; Mutation data; Neurotransmitter Agents; Psychotropic Drugs; Reproductive Effect; Sedative-hypnotic; Tranquilizing Agents

Nitrazepam Uses

1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5) is used as an anticonvulsant and hypnotic and it is used to controlled substance (depressant).

Nitrazepam Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	11mg/kg (11mg/kg)	BEHAVIORAL: EXCITEMENT VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996.
mouse	LD50	intraperitoneal	275mg/kg (275mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 165, 1972.
mouse	LD50	intravenous	130mg/kg (130mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01434,
mouse	LD50	oral	550mg/kg (550mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT	Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3206-79,
mouse	LD50	subcutaneous	> 400mg/kg (400mg/kg)	BEHAVIORAL: EXCITEMENT	Schweizerische Medizinische Wochenschrift. Vol. 95, Pg. 334, 1965.
rabbit	LD50	intravenous	520mg/kg (520mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 165, 1972.
rabbit	LD50	oral	520mg/kg (520mg/kg)		Schweizerische Medizinische Wochenschrift. Vol. 95, Pg. 334, 1965.
rat	LD50	intraperitoneal	733mg/kg (733mg/kg)	BEHAVIORAL: ANTICONVULSANT	Journal of Medicinal Chemistry. Vol. 20, Pg. 952, 1977.
rat	LD50	oral	825mg/kg (825mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Nitrazepam Consensus Reports

EPA Genetic Toxicology Program.

Nitrazepam Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5):
Hazard Codes: Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36/37/39
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 3249
WGK Germany: 3
RTECS: DF2450000
HazardClass: 6.1(b)
PackingGroup: III

Nitrazepam Specification

1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5), its Synonyms are 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on ; 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one ; 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one ; Apodorm ; Atempol ; Cerson ; Dormicum ; Dormicum (anticonvulsant) ; Dormin-5 ; Dormo-Puren ; Dumolid ; Mogadon ; N-Desmethylnimetazepam ; Nitrazepam .