- Nomifensine
- Nomifensine maleate
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| Name |
Nomifensine maleate |
EINECS | N/A |
| CAS No. | 32795-47-4 | Density | 1.114g/cm3 |
| PSA | 103.86000 | LogP | 3.07700 |
| Solubility | N/A | Melting Point |
199-201° |
| Formula | C16H18N2•C4H4O4 | Boiling Point | 378.4°Cat760mmHg |
| Molecular Weight | 354.406 | Flash Point | 164°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: heart rate changes, blood pressure elevation. Experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NOx. See also NOMIFENSINE. | Risk Codes | 22-36/37/38 |
| Molecular Structure |
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Hazard Symbols |
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| Synonyms |
1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin(z)-2-butenedioate;1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolinmaleate;8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolinemaleate;alival(antidepressant);hoe984;hostalival;merital;meritalam |
Nomifensine maleate Chemical Properties
IUPAC Name: but-2-Enedioic acid; 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
Synonyms of Nomifensine maleate (CAS NO.32795-47-4) : 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine (2Z)-but-2-enedioate (1:1) ; 8-isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (2Z)-2-butenedioate (1:1) ; 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate salt
InChI:InChI=1/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Product Categories: API;Heterocycles series
CAS NO:32795-47-4
Molecular Formula:C20H22N2O4
Molecular Weight :354.4
Molecular Structure :.png)
EINECS: 251-223-7
Flash Point: 343.8 °C
Enthalpy of Vaporization: 95.13 kJ/mol
Boiling Point: 644.8 °C at 760 mmHg
Vapour Pressure: 1.61E-16 mmHg at 25°C
Nomifensine maleate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | intravenous | 1429ug/kg/20M (1.429mg/kg) | CARDIAC: CHANGE IN RATE VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION ENDOCRINE: OTHER CHANGES | Clinical Pharmacology and Therapeutics Vol. 41, Pg. 88, 1987. |
| man | TDLo | oral | 66429ug/kg/31 (66.429mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Canadian Medical Association Journal. Vol. 133, Pg. 207, 1985. |
| mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 1019, 1984. |
| mouse | LD50 | intravenous | 68mg/kg (68mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 1019, 1984. |
| mouse | LD50 | oral | 300mg/kg (300mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 1019, 1984. |
| mouse | LD50 | subcutaneous | 195mg/kg (195mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 1019, 1984. |
| rabbit | LD50 | intravenous | > 32mg/kg (32mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 45, 1973. |
| rabbit | LD50 | oral | 854mg/kg (854mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 45, 1973. |
| rat | LD50 | intraperitoneal | 112mg/kg (112mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 1019, 1984. |
| rat | LD50 | intravenous | 66mg/kg (66mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 1019, 1984. |
| rat | LD50 | oral | 430mg/kg (430mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 45, 1973. |
| rat | LD50 | subcutaneous | 193mg/kg (193mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 27, Pg. 1019, 1984. |
Nomifensine maleate Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: heart rate changes, blood pressure elevation. Experimental reproductive effects. An antidepressant. When Nomifensine maleate (CAS NO.32795-47-4) is heated to decomposition, it emits toxic fumes of NOx. See also NOMIFENSINE.
Hazard Codes 
Xn
Risk Statements 22-36/37/38
R22: Nomifensine maleate (CAS NO.32795-47-4) is harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR 3249
WGK Germany 3
RTECS NX4912800
HazardClass 6.1(b)
PackingGroup III
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