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Oleandomycin phosphate

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Name

Oleandomycin phosphate

EINECS N/A
CAS No. 7060-74-4 Density N/A
PSA 253.55000 LogP 0.97990
Solubility N/A Melting Point 145-147℃
Formula C35H61NO12•H3O4P Boiling Point N/A
Molecular Weight 785.97 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of POx and NOx. See also PHOSPHATES. Risk Codes N/A
Molecular Structure Molecular Structure of 7060-74-4 (OLEANDOMYCIN PHOSPHATE) Hazard Symbols N/A
Synonyms

OleandomycinPhosphate

 

Oleandomycin phosphate Synthetic route

7060-74-4

oleandomycin phosphate

64774-87-4

8-methylene-oleandomycin

Conditions
ConditionsYield
With chromium dichloride In water; acetone at 20℃; for 0.75h;

Oleandomycin phosphate Chemical Properties

IUPAC Name: (3S,5S,6S,7R,8S,9R,12R,13R,14S,15R)-6-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-hydroxy-8-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl]oxy-5,7,9,12,13,15-hexamethyl-1,11-dioxaspiro[2.13]hexadecane-10,16-dione; phosphoric acid
Synonyms: (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-Hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside phosphate (1:1) ; 1,9-Dioxaspiro[2.13]hexadecane-4,10-dione, 12-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-, phosphate (1:1) (salt) ; Matromycin (phosphate) ; Oleandomycin phosphate (JAN)
CAS NO:7060-74-4
Molecular Formula of Oleandomycin phosphate (CAS NO.7060-74-4) :C35H64NO16P
Molecular Weight of Oleandomycin phosphate (CAS NO.7060-74-4) :785.85
Molecular Structure of Oleandomycin phosphate (CAS NO.7060-74-4) :
EINECS: 230-351-7
Flash Point: 518 °C
Enthalpy of Vaporization: 153.99 kJ/mol
Boiling Point: 932.9 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Storage temp: 0-6°C

Oleandomycin phosphate Uses

 Oleandomycin phosphate (CAS NO.7060-74-4) is effective against staphylococci, streptococci, pneumococci, and some Gram-negative bacteria.

Oleandomycin phosphate Production

 Oleandomycin phosphate (CAS NO.7060-74-4) is an antibiotic substance produced by species of Streptomyces .antibioticus.

Oleandomycin phosphate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 400mg/kg (400mg/kg)   Drugs in Japan Vol. 6, Pg. 164, 1982.
mouse LD50 oral 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 164, 1982.
mouse LD50 subcutaneous 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 164, 1982.
rat LD50 intravenous 480mg/kg (480mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Antibiotics and Chemotherapy Vol. 7, Pg. 419, 1957.

Oleandomycin phosphate Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of POx and NOx. See also PHOSPHATES.
Safety Statements 22-24/25
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes.
RIDADR UN2811 6.1/PG 2
RTECS RJ9800000

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