CAS No.7060-74-4,OLEANDOMYCIN PHOSPHATE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	7060-74-4
Name:	OLEANDOMYCIN PHOSPHATE

Formula:	C₃₅H₆₁NO₁₂•H₃O₄P
Molecular Weight:	785.97
Synonyms:	OleandomycinPhosphate
Melting Point:	145-147℃
Safety:	Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of PO_x and NO_x. See also PHOSPHATES.
PSA:	253.55000
LogP:	0.97990

Synthetic route

: 7060-74-4
oleandomycin phosphate

: 64774-87-4
8-methylene-oleandomycin

Conditions

Conditions	Yield
With chromium dichloride In water; acetone at 20℃; for 0.75h;

Total:37 Page 1 of 1 1

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Chemistry

IUPAC Name: (3S,5S,6S,7R,8S,9R,12R,13R,14S,15R)-6-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-hydroxy-8-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyl-tetrahydropyran-2-yl]oxy-5,7,9,12,13,15-hexamethyl-1,11-dioxaspiro[2.13]hexadecane-10,16-dione; phosphoric acid
Synonyms: (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-Hydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-14-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1,9-dioxaspiro[2.13]hexadec-12-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside phosphate (1:1) ; 1,9-Dioxaspiro[2.13]hexadecane-4,10-dione, 12-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-6-hydroxy-5,7,8,11,13,15-hexamethyl-14-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-, phosphate (1:1) (salt) ; Matromycin (phosphate) ; Oleandomycin phosphate (JAN)
CAS NO:7060-74-4
Molecular Formula of Oleandomycin phosphate (CAS NO.7060-74-4) :C₃₅H₆₄NO₁₆P
Molecular Weight of Oleandomycin phosphate (CAS NO.7060-74-4) :785.85
Molecular Structure of Oleandomycin phosphate (CAS NO.7060-74-4) :
EINECS: 230-351-7
Flash Point: 518 °C
Enthalpy of Vaporization: 153.99 kJ/mol
Boiling Point: 932.9 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Storage temp: 0-6°C

Uses

Oleandomycin phosphate (CAS NO.7060-74-4) is effective against staphylococci, streptococci, pneumococci, and some Gram-negative bacteria.

Production

Oleandomycin phosphate (CAS NO.7060-74-4) is an antibiotic substance produced by species of Streptomyces .antibioticus.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	400mg/kg (400mg/kg)		Drugs in Japan Vol. 6, Pg. 164, 1982.
mouse	LD50	oral	4gm/kg (4000mg/kg)		Drugs in Japan Vol. 6, Pg. 164, 1982.
mouse	LD50	subcutaneous	1gm/kg (1000mg/kg)		Drugs in Japan Vol. 6, Pg. 164, 1982.
rat	LD50	intravenous	480mg/kg (480mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Antibiotics and Chemotherapy Vol. 7, Pg. 419, 1957.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of PO_x and NO_x. See also PHOSPHATES.
Safety Statements 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
RIDADR UN2811 6.1/PG 2
RTECS RJ9800000