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PIPES
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  • Name PIPES
  • EINECS227-057-6
  • CAS No. 5625-37-6
  • Density1.505 g/cm3
  • PSA131.98000
  • LogP0.41700
  • Solubility0.1 M NaOH: 0.25 g/mL, clear, colorless
  • Melting Point>300 °C(lit.)
  • FormulaC8H18N2O6S2
  • Boiling PointN/A
  • Molecular Weight302.373
  • Flash PointN/A
  • Transport InformationN/A
  • AppearanceWhite/clear crystalline powder
  • Safety22-24/25-37/39-26
  • Risk Codes36/37/38
  • Molecular Structure
    Molecular Structure of 5625-37-6 (PIPES)
  • Hazard SymbolsIrritantXi
  • SynonymsIrritantXi
  • Article Data3

PIPES Synthetic route

110-85-0

piperazine

15484-44-3

Na-salt of 2-chloroethane-1-sulfonic acid

5625-37-6

2,2'-piperazine-1,4-diyl-bis-ethanesulfonic acid

Conditions
ConditionsYield
With sodium hydroxide In water for 3h; pH=9 - 9.5;86.3%
5625-37-6

2,2'-piperazine-1,4-diyl-bis-ethanesulfonic acid

A

131543-46-9

Glyoxal

B

25127-57-5

2,2'-Ethylendiimido-diethansulfonsaeure

Conditions
ConditionsYield
With (batho)2CuII (batho = 2,9-dimethyl-4,7-diphenyl-1,10-phenanthrolinedisulfonate); water at 25℃; for 24h; Rate constant; pH 8;
100-97-0

hexamethylenetetramine

563-63-3

silver(I) acetate

5625-37-6

2,2'-piperazine-1,4-diyl-bis-ethanesulfonic acid

2Ag(1+)*(CH2)4N2(CH2CH2SO3)2(2-)*2N4(CH2)6*14H2O=[Ag2(C8H16N2O6S2)(C6H12N4)2(H2O)2]*12H2O

Conditions
ConditionsYield
In ammonia; water aq. NH3; acid and amine added to aq. soln. of AgCH3COO; stirred for 15 min; ppt. dissolved by dropwise addn. of aq. NH3; soln. evapd. for 2 d at room temp.;

ammonium metavanadate

cobalt(II) chloride hexahydrate

5625-37-6

2,2'-piperazine-1,4-diyl-bis-ethanesulfonic acid

2C8H18N2O6S2*3Co(2+)*18H2O*10V(5+)*28O(2-)

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 1.5h; pH=6;

PIPES Chemical Properties

IUPAC Name: 2-[4-(2-Sulfoethyl)piperazin-1-yl]ethanesulfonic acid 
Empirical Formula: C8H18N2O6S2
Molecular Weight: 302.3683g/mol
EINECS: 227-057-6 
Structure of PIPES (CAS NO.5625-37-6):

Index of Refraction: 1.566
Molar Refractivity: 65.51 cm3
Molar Volume: 200.8 cm3
Polarizability: 25.97×10-24cm3
Surface Tension: 63.5 dyne/cm
Density: 1.505 g/cm3 
Physical Appearance: White/clear crystalline powder
Melting Point: >300 °C(lit.)
storage temp.: Store at RT.
solubility: 0.1 M NaOH: 0.25 g/mL, clear, colorless
Product Categories: Biochemistry; Good's Buffers; Buffer 
Canonical SMILES: C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O
InChI: InChI=1S/C8H18N2O6S2/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16/h1-8H2,(H,11,12,13)(H,14,15,16)
InChIKey: IHPYMWDTONKSCO-UHFFFAOYSA-N

PIPES Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-26 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S37/39:Wear suitable gloves and eye/face protection. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3

PIPES Specification

  PIPES , its cas register number is 5625-37-6. It also can be called 1,4-Piperazinebis(ethanesulfonic acid) ; Piperazine-N,N'-bis(2-ethanesulfonic acid) ; PIPES . PIPES (CAS NO.5625-37-6) is a white/clear crystalline powder which is irritating to eyes, respiratory system and skin.

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