- 57248-89-2(1,1-diphenyl-4-pyrrolidin-1-yl-but-2-ynoxy)phosphonic acid
- 57-24-9Strychnidin-10-one
- 5725-89-33H-Phenoxazin-3-one,7-methoxy-
- 5725-91-73H-Phenoxazin-3-one,7-ethoxy-
- 57260-67-01-(3,4-Dichlorophenyl)piperazine
- 57260-70-51-Piperazinecarboxylicacid, 4-(phenylmethyl)-, 1,1-dimethylethyl ester
- 57260-71-6tert-Butyl 1-piperazinecarboxylate
- 57260-72-71-Piperazinecarboxylicacid, 1,1-dimethylethyl ester
- 57260-73-8Carbamic acid,N-(2-aminoethyl)-, 1,1-dimethylethyl ester
- 5726-19-2Cyclohexanol,2-methyl-, 1-acetate
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
| Name |
Pamidronate disodium salt |
EINECS | 260-647-1 |
| CAS No. | 57248-88-1 | Density | N/A |
| PSA | 186.59000 | LogP | -0.08660 |
| Solubility | 28 mg/mL in water | Melting Point |
300 °C |
| Formula | C3H9NNa2O7P2 | Boiling Point | 658.7 °C at 760 mmHg |
| Molecular Weight | 279.03 | Flash Point | 352.2 °C |
| Transport Information | N/A | Appearance | White Crystals |
| Safety | 22-26-36/37/39-45 | Risk Codes | 22-48-41-37/38-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Phosphonicacid, (3-amino-1-hydroxypropylidene)bis-, disodium salt (9CI);3-Amino-1-hydroxypropane-1,1-diphosphonicacid disodium salt;APD;Aminomux;Aredia;CGP 23339A;CGP 23339AE;Disodium3-amino-1-hydroxypropane-1,1-diphosphonate;Pamidronic acid disodium salt; |
Pamidronate disodium salt Chemical Properties
Molecular Structure of Pamidronate disodium salt (CAS NO.57248-88-1):
.gif)
IUPAC Name: disodium [3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate
Empirical Formula: C3H9NNa2O7P2
Molecular Weight: 279.0331
H bond acceptors: 8
H bond donors: 7
Freely Rotating Bonds: 6
Polar Surface Area: 125.15Å2
Flash Point: 352.2 °C
Enthalpy of Vaporization: 111 kJ/mol
Boiling Point: 658.7 °C at 760 mmHg
Vapour Pressure: 3.79E-20 mmHg at 25°C
Melting point: 300 °C
Storage temp: 2-8°C
Solubility H2O: 28 mg/mL
InChI
InChI=1/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
Smiles
C(P(=O)([O-])O)(P(=O)([O-])O)(CCN)O.[Na+].[Na+]
EINECS: 260-647-1
Product Categories: Pharmaceutical material and intermeidates; Bone Resorption Inhibitor; All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Phosphorylating and Phosphitylating Agents; API's
Pamidronate disodium salt Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 20mg/kg (20mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 2408, 1994. | |
| man | TDLo | oral | 750ug/kg/5D-I (0.75mg/kg) | SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Australian and New Zealand Journal of Medicine. Vol. 24, Pg. 320, 1994. |
| mouse | LD50 | intraperitoneal | 190mg/kg (190mg/kg) | British UK Patent Application. Vol. #2096889, | |
| mouse | LD50 | intravenous | 45mg/kg (45mg/kg) | British UK Patent Application. Vol. #2096889, | |
| mouse | LD50 | oral | 625mg/kg (625mg/kg) | British UK Patent Application. Vol. #2096889, | |
| rat | LD50 | intravenous | 50mg/kg (50mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 2408, 1994. | |
| women | TDLo | intravenous | 600ug/kg/6H-C (0.6mg/kg) | Lancet. Vol. 1, Pg. 622, 1987. | |
| women | TDLo | intravenous | 900ug/kg (0.9mg/kg) | MUSCULOSKELETAL: JOINTS | Annals of Pharmacotherpy. Vol. 31, Pg. 499, 1997. |
Pamidronate disodium salt Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22-48-41-37/38-20/21/22
R22:Harmful if swallowed.
R48:Danger of serious damage to health by prolonged exposure.
R41:Risk of serious damage to the eyes.
R37/38:Irritating to respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-26-36/37/39-45
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: SZ6525000
Pamidronate disodium salt Specification
Pamidronate disodium salt , with CAS number of 57248-88-1, can be called (3-Amino-1-hydroxypropylidene)diphosphonic acid disodium salt ; Aminohydroxypropylidene diphosphonate disodium salt ; Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate ; Pamidronic acid disodium salt . It is a white solid, can be used as a bisphosphonate antiresorptive agent.resorption inhibitor.
What can I do for you?
Get Best Price
