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| CAS No.: | 127045-41-4 |
|---|---|
| Name: | Pazufloxacin |
| Molecular Structure: | |
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|
|
| Formula: | C16H15FN2O4 |
| Molecular Weight: | 318.305 |
| Synonyms: | Pasil;Pasil (TN);PZFX;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-, (S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6- carboxylic acid,10-(1-aminocyclopropyl)-9- fluoro-2,3-dihydro-3-methyl-7-oxo-,(3S)-;T 3761;(-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-;T-3761;Pazufloxacin Mesylas;Pazufloxaxin;(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methy...; |
| EINECS: | 635-036-1 |
| Density: | 1.56 g/cm3 |
| Melting Point: | 269-271 °C |
| Boiling Point: | 531.5 °C at 760 mmHg |
| Flash Point: | 275.2 °C |
| Appearance: | like white to light yellow crystalline |
| Hazard Symbols: |
 Xn, C, F
|
| Risk Codes: | 20/21/22 |
| Safety: | 36/37 |
| PSA: | 94.55000 |
| LogP: | 2.44030 |
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Chemistry
Systematic Name: (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
Synonyms of Pazufloxacin (CAS NO.127045-41-4): (-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid ; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)- ; H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-, (S)-
Product Categories: BacteriostaticAntibiotics;ChinolonesAlphabetic;PA - PENAnalytical Standards;Pharmacology Standards;Antibiotics;Chemical Structure;Chromatography;P;Principle;API's
CAS NO:127045-41-4
Molecular Formula: C16H15FN2O4
Molecular Weight: 318.3
Molecular Structure:
Index of Refraction: 1.692
Surface Tension: 76.4 dyne/cm
Density: 1.56 g/cm3
Flash Point: 275.2 °C
Enthalpy of Vaporization: 84.94 kJ/mol
Boiling Point: 531.5 °C at 760 mmHg
Vapour Pressure: 4E-12 mmHg at 25°C
Melting Point: 269-271°C
Uses
Pazufloxacin (CAS NO.127045-41-4) is used for the treatment of acute and chronic pneumonia, respiratory infections and other illnesses.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD | oral | > 2gm/kg (2000mg/kg) | Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. | |
| dog | LDLo | intravenous | 400mg/kg (400mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING | Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| mouse | LD | oral | > 5gm/kg (5000mg/kg) | Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. | |
| mouse | LD | subcutaneous | > 5gm/kg (5000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| mouse | LD50 | intravenous | 783mg/kg (783mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| rat | LD | oral | > 5gm/kg (5000mg/kg) | Chemotherapy Vol. 43(Suppl, | |
| rat | LD | subcutaneous | > 5gm/kg (5000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
| rat | LD50 | intravenous | 341mg/kg (341mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995. |
Safety Profile
Hazard Codes: 
Xn,
C,
F
Risk Statements: 20/21/22-34-11
R11: Pazufloxacin (CAS NO.127045-41-4) is highly flammable.
R34: Causes burns.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 45-36/37/39-26-16
S16: Keep Pazufloxacin (CAS NO.127045-41-4) away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RTECS: UU8815300