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Conditions | Yield |
---|---|
With sodium carbonate In water at 0 - 20℃; for 3h; pH=4; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 26℃; | 92% |
In dimethyl sulfoxide for 4h; Ambient temperature; |
N-chloromethyl-N-methylbenzamide
Penicillin G sodium
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (benzoyl-methyl-amino)-methyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran Ambient temperature; | 89% |
α-bromo-4,5-dimethoxy-2-nitrophenylacetic acid allyl ester
Penicillin G sodium
penicillin G α-allyloxycarbonyl-4,5-dimethoxy-2-nitrobenzyl ester
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; | 84% |
6-nitroveratrylbromide
Penicillin G sodium
2-nitro-4,5-dimethoxy-benzyl-6-β-(2-phenylacetamido)penicillinate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 17h; | 81% |
Chloromethyl pivalate
Penicillin G sodium
(pivaloyloxy)methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 24h; Ambient temperature; | 80% |
Penicillin G sodium
p-Methoxybenzyl bromide
benzylpenicillin 4-methoxybenzyl ester
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; | 80% |
1-(chloromethyl)pyrrolidin-2-one
Penicillin G sodium
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2-oxo-pyrrolidin-1-ylmethyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran Ambient temperature; | 79% |
Conditions | Yield |
---|---|
With sodium carbonate In water at 0 - 20℃; for 3h; pH=4; Inert atmosphere; | 77% |
Conditions | Yield |
---|---|
In water for 0.0833333h; | 67% |
The Penicillin G Sodium, with the CAS registry number 69-57-8 and EINECS registry number 200-710-2, has the systematic name of sodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate. And the molecular formula of this chemical is C16H17N2NaO4S. It is a kind of white powder, and has a good solubility in water. What's more, it should be stored at 2-8°C.
The physical properties of Penicillin G Sodium are as following: (1)ACD/LogP: 1.67; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.31; (4)ACD/LogD (pH 7.4): -2.06; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 103.22 Å2; (13)Flash Point: 355 °C; (14)Enthalpy of Vaporization: 102.51 kJ/mol; (15)Boiling Point: 663.3 °C at 760 mmHg; (16)Vapour Pressure: 1.69E-18 mmHg at 25°C.
Preparation and uses of Penicillin G Sodium: It can be obtained by fermentation of seperated penicilumchryso-genum. It is used in the treatment of a variety of infections. And it is effective against most gram-positive bacteria and against gram-negative cocci. What's more, it also has also been used as an experimental convulsant because of its actions on gamma-aminobutyric acid mediated synaptic transmission.
You should be cautious while dealing with this chemical. It may cause sensitization by inhalation and skin contact. Therefore, you had better take the following instructions: Wear suitable protective clothing and gloves; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); Do not breathe dust.
You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].O=C([O-])[C@@H]2N3C(=O)[C@@H](NC(=O)Cc1ccccc1)[C@H]3SC2(C)C
(2)InChI: InChI=1/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
(3)InChIKey: FCPVYOBCFFNJFS-WAGRTCGHBK
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | intramuscular | 60mg/kg (60mg/kg) | Laboratory Animal Science. Vol. 30, Pg. 524, 1980. | |
guinea pig | LDLo | intravenous | 150mg/kg (150mg/kg) | GASTROINTESTINAL: OTHER CHANGES | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959. |
mouse | LD50 | intracrebral | 3800ug/kg (3.8mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 23, 1959. |
mouse | LD50 | intramuscular | 2800mg/kg (2800mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959. | |
mouse | LD50 | intraperitoneal | 3314mg/kg (3314mg/kg) | Antibiotics Annual. Vol. 3, Pg. 540, 1955/1956. | |
mouse | LD50 | intravenous | 1500mg/kg (1500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959. |
mouse | LD50 | oral | > 4gm/kg (4000mg/kg) | Antibiotics Annual. Vol. 3, Pg. 540, 1955/1956. | |
mouse | LD50 | subcutaneous | 4750mg/kg (4750mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 23, 1959. | |
rat | LD50 | intravenous | 3020mg/kg (3020mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959. |
rat | LD50 | oral | 6916mg/kg (6916mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: OTHER CHANGES | Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 39, Pg. 259, 1978. |
rat | LD50 | parenteral | 2900ug/kg (2.9mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 863, 1965. |