- Phenylhydrazine
- Phenylhydrazine hydrochloride
- Phenylhydrazine sulfate
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Cas Database |
| Name |
Phenylhydrazine hydrochloride |
EINECS | 200-444-7 |
| CAS No. | 59-88-1 | Density | 1.125g/cm3 |
| PSA | 38.05000 | LogP | 2.54750 |
| Solubility | 50 g/L (20 ºC) | Melting Point |
250-254 °C (dec.)(lit.) |
| Formula | C6H8N2.HCl | Boiling Point | 243 °C at 760 mmHg |
| Molecular Weight | 144.604 | Flash Point | 115.4 °C |
| Transport Information | UN 2811 6.1/PG 3 | Appearance | white to tan solid |
| Safety | 53-45-61 | Risk Codes | 45-23/24/25-36/38-43-48/23/24/25-50-68 |
| Molecular Structure |
|
Hazard Symbols |
 T,  N
|
| Synonyms |
Hydrazine,phenyl-, monohydrochloride (8CI,9CI);N-Phenylhydrazine hydrochloride;Phenylhydrazine monohydrochloride;Phenylhydrazinium chloride;Phenylhydrazinehydrochloride; |
Article Data | 57 |
Phenylhydrazine hydrochloride Synthetic route
| Conditions | Yield |
|---|---|
| Stage #1: aniline With hydrogenchloride; sodium nitrite In water at 0℃; for 1h; Stage #2: With hydrogenchloride; tin(ll) chloride In water at 20℃; for 2h; | 98% |
| Stage #1: aniline With hydrogenchloride In water for 0.166667h; Cooling with ice; Stage #2: With sodium nitrite In water for 1h; Cooling with ice; Stage #3: With hydrogenchloride; tin(ll) chloride In water for 3h; Cooling with ice; | 94.1% |
| Stage #1: aniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: With sodium sulfite In water at 80℃; for 2h; Stage #3: With hydrogenchloride In water at 100℃; for 2h; | 94% |
- 65578-58-7
di-tert-butyl 1-phenylhydrazine-1,2-dicarboxylate
- 59-88-1
phenylhydrazine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In 1,4-dioxane; isopropyl alcohol for 0.25h; Heating; | 88% |
| Conditions | Yield |
|---|---|
| Stage #1: iodobenzene With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide In water at 80℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube; Stage #2: With hydrazine hydrate In water at 80℃; Inert atmosphere; Schlenk technique; Sealed tube; Stage #3: With hydrogenchloride In water pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube; | 87% |
| Conditions | Yield |
|---|---|
| With chloroform at 60℃; | A 85% B 0.5 g |
| Conditions | Yield |
|---|---|
| Stage #1: bromobenzene With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide In water at 80℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube; Stage #2: With hydrazine hydrate In water at 80℃; Inert atmosphere; Schlenk technique; Sealed tube; Stage #3: With hydrogenchloride In water pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube; | 85% |
| Stage #1: bromobenzene With potassium phosphate; N,N'-bis(2,5-dimethylpyrrol-1-yl)oxalamide; cetyltrimethylammonim bromide; copper(I) bromide In water at 110℃; for 0.166667h; Sealed tube; Inert atmosphere; Stage #2: With hydrazine hydrate In water at 110℃; for 1h; Sealed tube; Inert atmosphere; Stage #3: With hydrogenchloride In dichloromethane; water | 71% |
| Multi-step reaction with 2 steps 1: bis(triphenylphosphine)nickel(II) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; sodium t-butanolate / 1,4-dioxane / 5 h / 50 °C / Inert atmosphere 2: hydrogenchloride / water / 20 °C View Scheme |
- 91363-25-6
phenylazobenzenethiosulfonate
- 59-88-1
phenylhydrazine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium sulfite at 40 - 60℃; for 4h; | 79% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 20℃; | 56% |
- 53643-43-9, 61893-91-2, 106423-29-4
but-2-ene-1,4-diylbis(triphenylphosphinium) dichloride
- 100-63-0
phenylhydrazine
A
- 1092094-57-9
C24H21N2P*ClH
B
- 1299467-45-0
triphenyl(4-phenylhydrazonobut-2-enyl)phosphonium chloride
D
- 59-88-1
phenylhydrazine hydrochloride
E
- 791-28-6
Triphenylphosphine oxide
| Conditions | Yield |
|---|---|
| In chloroform at 55 - 57℃; for 10h; | A 19% B 46% C 7% D 0.37 g E 34% |
- 125329-73-9, 57127-49-8
{Et4N}{oxomolybdenum(Cl)4(H2O)}
- 100-63-0
phenylhydrazine
B
- 59-88-1
phenylhydrazine hydrochloride
| Conditions | Yield |
|---|---|
| In propan-1-ol addn. of org. compd. to suspn. of Mo-compd. in propanol, stirring (5 h, room temp.); filtn., standing (room temp., 48 h); elem. anal.; | A 39% B n/a |
Phenylhydrazine hydrochloride Consensus Reports
Phenylhydrazine hydrochloride Standards and Recommendations
Phenylhydrazine hydrochloride Specification
The Phenylhydrazine hydrochloride is an organic compound with the formula C6H8N2.HCl. The IUPAC name of this chemical is phenylhydrazine hydrochloride. With the CAS registry number 59-88-1, it is also named as Phenylhydrazinium Chloride. The product's categories are Hydrazines; Nitrogen Compounds; Organic Building Blocks; Food & Beverage; Reagents for Analysis of Carbohydrates; Reagents for Food Analysis; HydrazinesStains and Dyes; P; Stains & Dyes, A to. Besides, it is a white to tan solid, which should be stored in a closed cool and dry place. It is used as intermediates in medicine, pesticide and dye.
Physical properties about Phenylhydrazine hydrochloride are: (1)ACD/LogP: 1.25 ; (2)ACD/LogD (pH 5.5): 1.04; (3)ACD/LogD (pH 7.4): 1.25; (4)ACD/BCF (pH 5.5): 3.26; (5)ACD/BCF (pH 7.4): 5.21; (6)ACD/KOC (pH 5.5): 70.82; (7)ACD/KOC (pH 7.4): 113.16; (8)#H bond acceptors: 2; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 6.48 Å2; (12)Flash Point: 115.4 °C; (13)Enthalpy of Vaporization: 48 kJ/mol; (14)Boiling Point: 243 °C at 760 mmHg; (15)Vapour Pressure: 0.0329 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
It is toxic by inhalation, in contact with skin and if swallowed. It may cause sensitisation by skin contact and may cause cancer. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. It is very toxic to aquatic organisms. When you are using it, avoid release to the environment. Refer to special instructions/safety data sheet. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)SMILES: Cl.NNc1ccccc1
(2)InChI: InChI=1/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H CopyCopied
(3)InChIKey: JOVOSQBPPZZESK-UHFFFAOYAS
(4)Std. InChI: InChI=1S/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H
(5)Std. InChIKey: JOVOSQBPPZZESK-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 900ug/kg (0.9mg/kg) | Quarterly Journal of Crude Drug Research. Vol. 9, Pg. 1455, 1969. | |
| mouse | LD50 | oral | 2100mg/kg (2100mg/kg) | Quarterly Journal of Crude Drug Research. Vol. 9, Pg. 1455, 1969. | |
| mouse | LD50 | subcutaneous | 89mg/kg (89mg/kg) | Farmaco, Edizione Scientifica. Vol. 9, Pg. 274, 1954. | |
| rabbit | LDLo | oral | 25mg/kg (25mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| rabbit | LDLo | skin | 500mg/kg (500mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE | Fundamental and Applied Toxicology. Vol. 8, Pg. 583, 1987. |
| rabbit | LDLo | subcutaneous | 25mg/kg (25mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| rat | LD50 | intraperitoneal | 161mg/kg (161mg/kg) | Acta Biologica et Medica Germanica. Vol. 18, Pg. 617, 1967. |
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