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Polymyxin

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Name

Polymyxin

EINECS N/A
CAS No. 1406-11-7 Density 1.36g/cm3
PSA 545.79000 LogP 0.64470
Solubility N/A Melting Point N/A
Formula C48H82N16O14 Boiling Point °Cat760mmHg
Molecular Weight 1107.26348 Flash Point °C
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal, subcutaneous, and intravenous routes. An additive permitted in food for human consumption. Risk Codes N/A
Molecular Structure Molecular Structure of 1406-11-7 (Polymixin-B-Sulfate) Hazard Symbols N/A
Synonyms

Polymixin

 

Polymyxin Chemical Properties

Product Name: Polymyxin (CAS NO.1406-11-7)


Molecular Formula: C48H82N16O14
Molecular Weight: 1107.2635g/mol
Mol File: 1406-11-7.mol
Density: 1.36 g/cm3
Surface Tension: 76.4 dyne/cm
XLogP3-AA: -8
H-Bond Donor: 19
H-Bond Acceptor: 19
Structure Descriptors of Polymyxin (CAS NO.1406-11-7):
  InChI : InChI=1/C48H82N16O14/c1-24(2)22-34-44(73)57-28(10-16-49)38(67)56-31(13-19-52)42(71)63-36(25(3)65)46(75)54-21-15-33(41(70)55-29(11-17-50)40(69)61-35(45(74)60-34)23-27-8-6-5-7-9-27)58-39(68)30(12-18-51)59-47(76)37(26(4)66)64-43(72)32(14-20-53)62-48(77)78/h5-9,24-26,28-37,62,65-66H,10-23,49-53H2,1-4H3,(H,54,75)(H,55,70)(H,56,67)(H,57,73)(H,58,68)(H,59,76)(H,60,74)(H,61,69)(H,63,71)(H,64,72)(H,77,78)/t25-,26-,28+,29+,30+,31+,32+,33+,34+,35-,36+,37+/m1/s1    
  Smiles: CC(C)C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC(=O)[C@H](CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@@H](NC(=O)[C@H](CCN)NC(O)=O)[C@@H](C)O

Polymyxin Uses

Polymyxin antibiotics are considered relatively neurotoxic and nephrotoxic[6] and, though effective, are therefore used only if less toxic antibiotics are ineffective or are contraindicated. Typical use cases are infections with strains of Pseudomonas aeruginosa or Enterobacteriaceae species that are highly resistant to other types of antibiotics such as cephalosporins.
Polymyxins (CAS NO.1406-11-7) are used to neutralize or absorb LPS contaminating samples that are intended for use in e.g. immunological experiments. Minimization of LPS contamination can be important because LPS can evoke strong reactions from immune cells and therefore distort experimental results.

Polymyxin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 25mg/kg (25mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949.
mouse LD50 intraperitoneal 77mg/kg (77mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949.
mouse LD50 subcutaneous 250mg/kg (250mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949.

Polymyxin Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. An additive permitted in food for human consumption.

Polymyxin Specification

 Polymyxin ,its CAS NO. is 1406-11-7,the synonyms is B-71 ; Caswell No. 678 ; EPA Pesticide Chemical Code 006305 ; Polymyxinum .

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