IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 326.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 293.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 293.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); No Evidence: mouse CANCAR    Cancer. 40 (1977),1935. ; (ipr); Equivocal Evidence: rat CANCAR    Cancer. 40 (1977),1935. . Reported in EPA TSCA Inventory.

1. Introduction of Prednisone
Prednisone is a white crystalline powder and an organic compound. The systematic name of this chemical is 17,21-dihydroxypregna-1,4-diene-3,11,20-trione. The product's categories are Antitumors for Research and Experimental Use; Biochemistry; Hydroxyketosteroids; Steroids; Intermediates & Fine Chemicals; Pharmaceuticals; Steroid and Hormone. It is also named as 1,4-Pregnadiene-17a,21-diol-3,11,20-trione. In addition, the Classification Code of Prednisone is Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antineoplastic Agents; Antineoplastic agents, hormonal; Drug / Therapeutic Agent; Glucocorticoid; Glucocorticoids; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Mutation data; Reproductive Effect; Tumor data. Prednisone is practically insoluble in water.

2. Properties of Prednisone
Physical properties about Prednisone are:
(1)ACD/LogP: 1.57; (2)ACD/LogD (pH 5.5): 1.57; (3)ACD/LogD (pH 7.4): 1.57; (4)ACD/BCF (pH 5.5): 9.16; (5)ACD/BCF (pH 7.4): 9.16; (6)ACD/KOC (pH 5.5): 169.92; (7)ACD/KOC (pH 7.4): 169.92; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 69.67 Å²; (12)Index of Refraction: 1.603; (13)Molar Refractivity: 94.08 cm³; (14)Molar Volume: 273.6 cm³; (15)Polarizability: 37.29×10^-24cm³; (16)Surface Tension: 58.5 dyne/cm; (17)Density: 1.3 g/cm³; (18)Flash Point: 314.8 °C; (19)Enthalpy of Vaporization: 98.73 kJ/mol; (20)Boiling Point: 573.7 °C at 760 mmHg; (21)Vapour Pressure: 1.51E-15 mmHg at 25°C.

3. Structure Descriptors of Prednisone
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)\C=C/[C@]1(C)[C@H]4C(=O)C[C@@]23C
(2)InChI: InChI=1/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
(3)InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWBN
(4)Std. InChI: InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
(5)Std. InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWSA-N

4. Safety information of Prednisone
The toxicity data is as follows:

5. Safety information of Prednisone
Hazard Codes: Xn,C,F
Risk Statements: 63-34-11
63: Possible risk of harm to the unborn child.
34: Causes burns.
11: Highly Flammable.
Safety Statements: 36/37/39-45-26-16
36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
16: Keep away from sources of ignition - No smoking.
WGK Germany: 3
RTECS: TU4154100
HazardClass: IRRITANT

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and can cause burns. Please keep away from sources of ignition - No smoking. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is possible risk of harm to the unborn child. When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

6. Uses of Prednisone
Prednisone can be used to produce androsta-1,4-diene-3,11,17-trione by heating. It will need reagent MnO₂ and solvent CHCl₃ with reaction time of 4 hours. The yield is about 55.3%.

Besides, it is a white crystalline powder, which should be used in biochemical research. Adrenal cortex hormones drugs, it's anti-inflammatory, anti-allergy and commonly used in chemotherapy, you can improve patient general, and it can be used in acute leukemia and other tumors.

7. Production of Prednisone
Prednisone can be got from CORTISONE.