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| CAS No.: | 52-21-1 |
|---|---|
| Name: | Prednisolone-21-acetate |
| Molecular Structure: | |
|
|
|
| Formula: | C23H30O6 |
| Molecular Weight: | 402.488 |
| Synonyms: | Supercortyl;Prednisolone acetate;Prednidoren;Predicort;Pred-Forte;Pregna-1,4-diene-3,20-dione,11b,17,21-trihydroxy-, 21-acetate(6CI,7CI,8CI);11b,17a,21-Trihydroxypregna-1,4-diene-3,20-dione21-acetate;21-Acetoxy-11b,17-dihydroxypregna-1,4-diene-3,20-dione;Cormalone;Deltilen;Econopred;Falcon (steroid);Inflanefran;Meticortelone acetate;NSC 10966;Pred Mild; |
| EINECS: | 200-134-1 |
| Density: | 1.28 g/cm3 |
| Melting Point: | 240-244 °C |
| Boiling Point: | 579.8 °C at 760 mmHg |
| Flash Point: | 198.4 °C |
| Solubility: | 11.6mg/L(25 oC) |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 T, C, F
|
| Risk Codes: | 25-34-11 |
| Safety: | 45-36/37/39-26-16 |
| Transport Information: | UN 2811 6.1/PG 3 |
| PSA: | 100.90000 |
| LogP: | 2.12840 |
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| Conditions | Yield |
|---|---|
| With dmap In N,N-dimethyl-formamide at 40℃; for 0.5h; Inert atmosphere; | 99.8% |
| With pyridine | 98% |
| With pyridine | |
| With dmap at 60 - 65℃; for 6h; Time; | 55.1 g |
| With sodium acetate In tetrahydrofuran; acetone at 40℃; for 3h; Reagent/catalyst; Inert atmosphere; |
- 4224-31-1
21-acetoxy-9-bromo-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione
- 52-21-1
prednisolone 21-acetate
| Conditions | Yield |
|---|---|
| Stage #1: 21-acetoxy-9-bromo-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione With chromium(VI) oxide; mercaptoacetic acid; zinc In dimethyl sulfoxide; acetone at 15 - 20℃; Stage #2: With hydrogenchloride In water for 1h; Stage #3: With sodium thiosulfate In water for 0.333333h; Reagent/catalyst; | 92% |
- 50-03-3
hydrocortisone acetate
A
- 52-21-1
prednisolone 21-acetate
B
- 120612-05-7
21,21'-diacetoxy-11β,17,11'β,17'-tetrahydroxy-2,2'-diselanediyl-bis-pregna-1,4-diene-3,20-dione
| Conditions | Yield |
|---|---|
| With selenium(IV) oxide; acetic acid |
- 28449-43-6
21-acetoxy-11β-hydroxy-pregna-1,4,17(20)c-trien-3-one
- 52-21-1
prednisolone 21-acetate
| Conditions | Yield |
|---|---|
| With [bis(acetoxy)iodo]benzene |
- 52-21-1
prednisolone 21-acetate
| Conditions | Yield |
|---|---|
| With selenium(IV) oxide | |
| With iodine pentoxide |
- 52-21-1
prednisolone 21-acetate
| Conditions | Yield |
|---|---|
| With lithium carbonate; N,N-dimethyl-formamide; lithium bromide |
- 24916-88-9
21-acetoxy-9-chloro-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione
- 52-21-1
prednisolone 21-acetate
| Conditions | Yield |
|---|---|
| With potassium hydroxide; sodium hydroxide In tetrahydrofuran; PO4; dichloromethane; water; acetone |
- 52-21-1
prednisolone 21-acetate
| Conditions | Yield |
|---|---|
| With dmap; potassium hydroxide; sodium hydroxide; acetic anhydride; triethylamine In tetrahydrofuran; PO4; dichloromethane; water; acetone | |
| With dmap; potassium hydroxide; sodium hydroxide; acetic anhydride; triethylamine In tetrahydrofuran; PO4; n-heptane; dichloromethane; water; acetone |
- 96580-08-4
21-acetoxy-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione disemicarbazone
- 52-21-1
prednisolone 21-acetate
| Conditions | Yield |
|---|---|
| Stage #1: 21-acetoxy-11β,17-dihydroxy-pregna-1,4-diene-3,20-dione disemicarbazone With hydrogenchloride In chloroform; water at 25 - 30℃; for 0.5h; Stage #2: With sodium nitrite In chloroform; water at 18 - 22℃; for 6h; | 19.5 g |
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Chemistry
Product Name: [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Empirical Formula: C23H30O6
Molecular Weight: 402.4807
EINECS: 200-134-1
Index of Refraction: 1.587
Density: 1.28 g/cm3
Flash Point: 198.4 °C
Melting point: 240-244 °C
Appearance: white crystalline powder
Enthalpy of Vaporization: 99.6 kJ/mol
Boiling Point: 579.8 °C at 760 mmHg
Vapour Pressure: 7.36E-16 mmHg at 25 °C
Structure of Prednisolone-21-acetate (CAS NO.52-21-1):
Product Category of Prednisolone-21-acetate (CAS NO.52-21-1): Biochemistry;Hydroxyketosteroids;Steroids
Uses
Prednisolone-21-acetate (CAS NO.52-21-1) can be applied to rheumatoid arthritis, rheumatic fever, lupus, scleroderma, dermatomyositis, acute lymphatic leukemia, and so on.
Toxicity Data With Reference
| 1. | scu-mus TDLo:96 mg/kg (11D preg):TER | SEIJBO Senten Ijo. Congenital Anomalies. 13 (1973),245. | ||
| 2. | orl-rat TDLo:1800 mg/kg (2-19D preg):REP | FESTAS Fertility and Sterility. 22 (1971),735. | ||
| 3. | scu-mus LD50:3500 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),713. |
Safety Profile
Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of Prednisolone-21-acetate (CAS NO.52-21-1): 
T,
C,
F
Risk Statements: 25-34-11
R11:Highly flammable.
R25 :Toxic if swallowed.
R34:Causes burns.
Safety Statements: 45-36/37/39-26-16
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Specification
Prednisolone-21-acetate , its cas register number is 52-21-1. It also can be called Blephamide liquifilm ; Prednisolone acetate ; and 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate .