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| Name |
Procaine |
EINECS | 200-426-9 |
| CAS No. | 59-46-1 | Density | 1.077 g/cm3 |
| PSA | 55.56000 | LogP | 2.34860 |
| Solubility | 9.45g/L(30 oC) | Melting Point |
61oC |
| Formula | C13H20N2O2 | Boiling Point | 373.6 °C at 760 mmHg |
| Molecular Weight | 236.314 | Flash Point | 179.8 °C |
| Transport Information | UN 3249 | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Benzoicacid, p-amino-, 2-(diethylamino)ethyl ester (8CI);2-(Diethylamino)ethylp-aminobenzoate;2-Diethylaminoethyl 4-aminobenzoate;4-Aminobenzoic acid2-(diethylamino)ethyl ester;4-Aminobenzoic acid diethylaminoethyl ester;Diethylaminoethyl p-aminobenzoate;Duracaine;Nissocaine;PfizerpenAS;Procain;Procaine base;SP 01;Spinocaine;Vitamin H3;p-Aminobenzoic acid 2-diethylaminoethyl ester;b-(Diethylamino)ethyl p-aminobenzoate;b-Diethylaminoethyl4-aminobenzoate; |
Article Data | 33 |
Procaine Chemical Properties
Molecular Structure of Procaine (CAS NO.59-46-1):
.gif)
IUPAC Name: 2-diethylaminoethyl 4-aminobenzoate
Empirical Formula: C13H20N2O2
Molecular Weight: 236.310 g/mol
EINECS: 200-426-9
Melting Point: 61°C
Density: 1.077 g/cm3
Flash Point: 179.8 °C
Appearance: White crystal
Index of Refraction: 1.542
Enthalpy of Vaporization: 62.09 kJ/mol
Boiling Point: 373.6 °C at 760 mmHg
Vapour Pressure: 8.84E-06 mmHg at 25°C
Solubility: Soluble in water, slightly soluble in ethanol, slightly soluble in virtually insoluble in ether
InChI
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3
Smiles
c1(C(OCCN(CC)CC)=O)ccc(N)cc1
Classification Code: Anesthetics; Anesthetics, local; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; Human Data; Peripheral Nervous System Agents; Sensory System Agents
Procaine Uses
Procaine (CAS NO.59-46-1) is Local anesthesia. The low toxicity safety. Effect, rapidly Applicable to local anesthesia, used in the eyes, ears, nose, and so on, for infiltrating anesthesia branch operation, mentor anesthesia and close therapeutics, etc. The goods are used in the production of penicillin.
Procaine Production
For nitro benzoic acid and ethyl amide ethanol in dimethyl benzene 2 of backflow esterification nitro preparations, reoccupy iron powder reductiona procaine, then use hydrochloride got P-aminobenzoic acid-2-diethylamino ethyl ester (59-46-1).
Procaine Toxicity Data With Reference
| 1. | orl-man LDLo:147 mg/kg | 85DCAI Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73. | ||
| 2. | ims-wmn TDLo:1600 µg/kg:CNS | JNNPAU Journal of Neurology, Neurosurgery and Psychiatry. 34 (1971),20. | ||
| 3. | ipr-rat LDLo:280 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 1 (1959),156. | ||
| 4. | scu-rat LD50:600 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 104 (1956),388. | ||
| 5. | ivn-rat LDLo:45 mg/kg | PHREA7 Physiological Reviews. 12 (1932),190. | ||
| 6. | orl-mus LD50:350 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 16 (1966),1275. | ||
| 7. | ipr-mus LD50:124 mg/kg | RPOBAR Research Progress in Organic Biological and Medicinal Chemistry. 2 (1970),213. | ||
| 8. | scu-mus LD50:300 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 5 (1955),376. | ||
| 9. | ivn-mus LD50:45 mg/kg | JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 45 (1956),382. |
Procaine Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by parenteral route. Human systemic effects by intramuscular route: lack of muscular control, rigidity, and possibly catalepsy. See also ESTERS. When heated to decomposition it emits toxic fumes of NOx. Used as a local anesthetic.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Procaine Specification
Procaine , with CAS number of 59-46-1, can be called 2-(Diethylamino)ethyl 4-aminobenzoate ; 2-(Diethylamino)ethyl p-aminobenzoate ; 2-(Diethylamino)ethylp-aminobenzoate ; 2-Diethylaminoethyl4-aminobenzoate ; 2-Diethylaminoethylester kyseliny p-aminobenzoove ; 2-Diethylaminoethylesterkyselinyp-aminobenzoove ; 2-Diethylaminoethylp-aminobenzoate ; 4-Aminobenzoic acid diethylaminoethyl ester .