(+)-Isoborneol

Base Information Edit

Chemical Name:(+)-Isoborneol
CAS No.:507-70-0
Molecular Formula:C10H18O
Molecular Weight:154.252
Hs Code.:29061990
European Community (EC) Number:204-712-4,208-080-0
UN Number:1312
UNII:8GDX32M6KF
DSSTox Substance ID:DTXSID40168259
Nikkaji Number:J150.348K
Wikipedia:Isoborneol
Wikidata:Q27270411
Metabolomics Workbench ID:47073
ChEMBL ID:CHEMBL4294644
Mol file:507-70-0.mol

Synonyms:(+)-Isoborneol;Isoborneol, (+)-;(S,S,S)-(+)-Isoborneol;16725-71-6;UNII-8GDX32M6KF;8GDX32M6KF;Isoborneol, (1S,2S,4S)-(+)-;Isoborneol (1S,2S,4S)-form [MI];Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1S,2S,4S)-;(1S,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol;Isoborneol;1-Bornyl alcohol;(1S,4beta)-1alpha,7,7-Trimethylbicyclo[2.2.1]heptane-2beta-ol;epi-Borneol;Borneol, (1S,2R,4S)-(-)-;(?)-borneol;(1S - endo) - 1,7,7 - trimethylbicyclo(2.2.1)heptan - 2 - ol;SCHEMBL2469360;CHEMBL4294644;FEMA 2158;DTXSID40168259;CHEBI:191949;DTGKSKDOIYIVQL-OYNCUSHFSA-N;124-76-5;507-70-0;AKOS037643879;AS-39230;Q27270411;Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S-exo)-

Suppliers and Price of (+)-Isoborneol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Borneol
100mg
$ 255.00

TRC
Borneol
5g
$ 225.00

TCI Chemical
Borneol (contains ca. 20% Isoborneol) >70.0%(GC)
500g
$ 142.00

TCI Chemical
Borneol (contains ca. 20% Isoborneol) >70.0%(GC)
25g
$ 33.00

Sigma-Aldrich
(1S)-(-)-Borneol for synthesis
25 g
$ 76.96

Sigma-Aldrich
(1S)-(-)-Borneol for synthesis
250 g
$ 114.70

Sigma-Aldrich
(1S)-(-)-Borneol for synthesis
100 g
$ 111.92

JR MediChem
Borneol 98%
20mg
$ 100.00

DC Chemicals
Borneol >98%
20 mg
$ 280.00

Chem-Impex
Borneol,95-100%(GC),KOSHER,FEMA2157Hazmat 95-100%(GC)
2.5KG
$ 232.96

Total 108 raw suppliers

Chemical Property of (+)-Isoborneol Edit

Chemical Property:

Appearance/Colour:solid
Vapor Pressure:33.5 mm Hg ( 25 °C)
Melting Point:206-209 °C
Refractive Index:1.532
Boiling Point:212 °C at 760 mmHg
PKA:15.36±0.60(Predicted)
Flash Point:65.6 °C
PSA：20.23000
Density:0.992 g/cm³
LogP:2.19350
Water Solubility.:insoluble
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:154.135765193
Heavy Atom Count:11
Complexity:185
Transport DOT Label:Flammable Solid

Purity/Quality:

60.0% ^*data from raw suppliers

Borneol ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,Xi,Xn
Hazard Codes:F,Xi,Xn
Statements: 11-43-22
Safety Statements: 16-36/37

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Other Classes -> Alcohols and Polyols, Other
Canonical SMILES:CC1(C2CCC1(C(C2)O)C)C
Isomeric SMILES:C[C@]12CC[C@H](C1(C)C)C[C@@H]2O
Description Borneol, also called “compound long nao,” is a colorless and transparent crystal, which has a pungent, camphor-like odor and a burning taste reminiscent of mint. It occurs naturally in cinnamon leaf, ginger, Thymus, cardamom, coriander leaf, coriander seed, etc. Borneol has been shown to enhance blood-brain barrier (BBB) permeability and increase brain concentrations of drugs, as well as protect the brain and BBB while inducing no pathological damage. Thus, borneol is used as a promoter of drug absorption. Borneol is also used as a food additive permitted for direct addition to food for human consumption. l-Borneolum was originally from the Compositae Aenean Blumea balsamifera (L.) DC (Ai Na Xiang). Its crystals were made after being extracted from the fresh leaves of Ai Na Xiang. It is an optical isomer with natural borneol. It’s usually used for making spice the same as natural borneol, synthesized borneol, and so on .Ai Na Xiang is a traditional Chinese medicine alias as Da Feng Ai, Niu Er Ai, etc. It has been recorded firstly in Guang Zhi, “Ai Na Xiang came from the west country and looks like the artemisia.” It has been recorded in many Chinese materia medica books, such as Hai Yao Ben Cao, Ling Nan Cai Yaolu, etc. In Zhong hua Ben cao (Chinese Materia Medica), the literature described it as “Ai Na Xiang (l-borneolum) has the fragrance because it is like the artemisia. It can also be prepared to the borneol, so it is called “Bing Pian Ai.” It is believed that this is the earliest records that Ai Na Xiang was made into borneol . In China, the authentic product area of l-borneolum is in Luodian, Guizhou Province . There are no other plant resources reported for producing l-borneolum in China.
Physical properties Appearance: white translucent flakes, bulk or granular crystals. With a clear aroma, spicy, cool, volatile, black smoke, and yellow flame when lit without residue left. Melting point: 201–205? °C.? Soluble in ethanol, chloroform, or ether, almost insoluble in water. Specific optical rotation: ?36.5° to ?38.5° in 5% (g/mL) ethanol solution, stable under sealed condition at room temperature.Pungent, bitter, slightly cold; heart, spleen, and lung meridians entered. (In Chinese traditional medicine’s opinion)
Uses Perfumery, esters.
Indications Sore throat, aphthous, red eyes, purulent ear discharge, convulsions, febrile delirium, sudden faint due to qi depression, stroke, and coma
Clinical Use l-Borneolum is used as a kind of borneol in clinical usage all along, but its clinical usage is fewer than borneol considering its clinical efficacy is weaker than borneol. The main reasons may be the following aspects: the discovery of l-borneolum is later than borneol, and the processing technology of l-borneolum is far behind borneol which leads to high impurities. l-Borneolum has less adverse reactions the same as borneol, including gastrointestinal irritation, reproductive toxicity, and allergic reactions.

Technology Process of (+)-Isoborneol

There total 130 articles about (+)-Isoborneol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%