Trimethylacetic anhydride

Base Information Edit

Chemical Name:Trimethylacetic anhydride
CAS No.:1538-75-6
Molecular Formula:C10H18O3
Molecular Weight:186.251
Hs Code.:29159000
European Community (EC) Number:216-263-1
DSSTox Substance ID:DTXSID601014577
Nikkaji Number:J137F
Mol file:1538-75-6.mol

Synonyms:pivalic anhydride

Suppliers and Price of Trimethylacetic anhydride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TrimethylaceticAnhydride1538-75-6
100g
$ 155.00

TRC
TrimethylaceticAnhydride1538-75-6
250g
$ 350.00

TCI Chemical
Pivalic Anhydride >98.0%(GC)
25mL
$ 52.00

TCI Chemical
Pivalic Anhydride >98.0%(GC)
250mL
$ 264.00

SynQuest Laboratories
Trimethylacetic anhydride 97%
100 g
$ 160.00

SynQuest Laboratories
Trimethylacetic anhydride 97%
500 g
$ 616.00

Sigma-Aldrich
Trimethylacetic anhydride 99%
100g
$ 155.00

Sigma-Aldrich
Trimethylacetic anhydride 99%
25g
$ 50.40

Oakwood
Pivalic Anhydride 95%
10g
$ 20.00

Matrix Scientific
Trimethylacetic anhydride 97%
500g
$ 843.00

Total 69 raw suppliers

Chemical Property of Trimethylacetic anhydride Edit

Chemical Property:

Appearance/Colour:clear colourless liquid
Vapor Pressure:0.475mmHg at 25°C
Refractive Index:n20/D 1.409(lit.)
Boiling Point:193 °C at 760 mmHg
Flash Point:57.2 °C
PSA：43.37000
Density:0.958 g/cm³
LogP:2.14840
Storage Temp.:Store at RT.
Sensitive.:Moisture Sensitive
Solubility.:Miscible with acetonitrile.
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:186.125594432
Heavy Atom Count:13
Complexity:191

Purity/Quality:

98% ^*data from raw suppliers

TrimethylaceticAnhydride1538-75-6 ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Other Classes -> Acid Anhydrides, Other
Canonical SMILES:CC(C)(C)C(=O)OC(=O)C(C)(C)C
Uses A metabolite of a double prodrug (6-dGCV-DPiv Trimethylacetic anhydride was used:in solid-phase oligonucleotide synthesisin kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acidas acylation and esterification reagent for anilinesas acylation and esterification reagent for phenols

Technology Process of Trimethylacetic anhydride

There total 51 articles about Trimethylacetic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 3282-30-2
pivaloyl chloride

: 75-98-9
Trimethylacetic acid

: 1538-75-6
2,2-dimethylpropanoic anhydride

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c9nj01984g

Reference yield: 96.0%

: 56070-03-2
N-(chlorosulfinyl)diphenylketimine

: 75-98-9
Trimethylacetic acid

: 1538-75-6
2,2-dimethylpropanoic anhydride

Guidance literature:: In dichloromethane; for 2h; Ambient temperature;

Reference yield: 90.0%

: 75-98-9
Trimethylacetic acid

: 1538-75-6
2,2-dimethylpropanoic anhydride

Guidance literature:: With triethylamine; Phenyl N-phenylphosphoramidochloridate; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1055/s-1981-29391