1-Acetyl-2,2-diphenylcyclopropane

Base Information

• Chemical Name: 1-Acetyl-2,2-diphenylcyclopropane
• CAS No.: 27067-40-9
• Molecular Formula: C17H16 O
• Molecular Weight: 236.3083
• NSC Number: 120384
• Nikkaji Number: J1.868.992H
• Mol file: 27067-40-9.mol

Synonyms:NSC120384;27067-40-9;NSC-120384

Chemical Property of 1-Acetyl-2,2-diphenylcyclopropane

Chemical Property:

• Vapor Pressure: 2.7E-05mmHg at 25°C
• Boiling Point: 357.6°C at 760 mmHg
• Flash Point: 153.9°C
• Density: 1.118g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 236.120115130
• Heavy Atom Count: 18
• Complexity: 290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1CC1(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-Acetyl-2,2-diphenylcyclopropane

There total 16 articles about 1-Acetyl-2,2-diphenylcyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,1'-(2-ethynylcyclopropane-1,1-diyl)dibenzene (93319-68-7) → 1-(2,2-diphenylcyclopropyl)ethanone (27067-40-9)

Guidance literature:

With mercuric triflate-(N,N,N',N'-tetramethylurea)2; water; In methanol; at 25 ℃; Reagent/catalyst;

DOI:10.1021/jo401325t

Reference yield: 88.0%

2,2-diphenyl-cyclopropanecarboxylic acid (7150-12-1) + methyllithium (917-54-4) → 1-(2,2-diphenylcyclopropyl)ethanone (27067-40-9)

Guidance literature:

In diethyl ether; for 0.333333h;

DOI:10.1039/a802922i

Reference yield: 83.0%

1-bromo-2,2-diphenyl cyclopropane (32812-52-5) + acetyl chloride (75-36-5) → 1-(2,2-diphenylcyclopropyl)ethanone (27067-40-9)

Guidance literature:

1-bromo-2,2-diphenyl cyclopropane; With TurboGrignard; In tetrahydrofuran; 1,4-dioxane; at 25 ℃; for 48h;

acetyl chloride; With copper(I) cyanide*2 lithium chloride; In tetrahydrofuran; 1,4-dioxane; stereoselective reaction;

DOI:10.1055/s-0028-1087487

upstream raw materials:

2,2-diphenyl-cyclopropanecarboxylic acid

methyllithium

Dichlorodiphenylmethane

methyl vinyl ketone

Downstream raw materials:

(Z)-2-(2,2-diphenylcyclopropyl)-2-butene

(E)-2-(2,2-diphenylcyclopropyl)-2-butene

3-(2,2-Diphenylcyclopropyl)-3-methyl-1,1-diphenyl-1-buten

3-(2,2-Diphenylcyclopropyl)-3-methyl-1-phenyl-1-butanon