2-(2-Fluoro-phenoxy)-ethanol

Base Information

• Chemical Name: 2-(2-Fluoro-phenoxy)-ethanol
• CAS No.: 2924-65-4
• Molecular Formula: C8H9FO2
• Molecular Weight: 156.157
• Mol file: 2924-65-4.mol

Synonyms:

Chemical Property of 2-(2-Fluoro-phenoxy)-ethanol

Chemical Property:

• PSA: 29.46000
• LogP: 1.19680

Purity/Quality:

95% ^*data from raw suppliers

2-(2-Fluorophenoxy)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Fluoro-phenoxy)-ethanol

There total 3 articles about 2-(2-Fluoro-phenoxy)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.1%

2-fluorophenol (367-12-4) + 2-bromoethanol (540-51-2) → 2-(2-fluorophenoxy)ethan-1-ol (2924-65-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 30 ℃; for 2h;

Reference yield:

2-fluorophenol (367-12-4) + 2-chloro-ethanol (107-07-3) → 2-(2-fluorophenoxy)ethan-1-ol (2924-65-4)

Guidance literature:

With sodium hydroxide; In water; at 80 ℃;

DOI:10.1134/S1070363216060098

Reference yield:

→ 2-(2-fluorophenoxy)ethan-1-ol (2924-65-4)

Guidance literature:

Na-(2-fluor-phenolat) 1. Ethylenchlorhydrin, Bzl., Erhitzen 2. W.;

upstream raw materials:

2-fluorophenol

2-chloro-ethanol

2-bromoethanol

Downstream raw materials:

benzo-1,4-dioxane

N-(3-Chloro-4-methoxy-phenyl)-N'-cycloheptyl-6-[2-(2-fluoro-phenoxy)-ethoxy]-[1,3,5]triazine-2,4-diamine

Refernces

• 1、 Erkin,Klaptyuk,Gurzhii,Yuzikhin,Krutikov. "Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms". . p. 1274 - 1281. Retrieved 2016/08/10.