FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

Base Information

Chemical Name:FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
CAS No.:296774-32-8
Molecular Formula:C20H19NO5
Molecular Weight:353.375
Hs Code.:
Mol file:296774-32-8.mol

Synonyms:trans-N-[(9-fluorenylmethoxy)carbonyl]-3-hydroxy-L-proline;erythro Cbz-phenylalanyl chlorohydrin;(2S,3S)-3-benzyloxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane;3(S)-N-(benzyloxycarbonyl)-amino-1-chloro-2(syn)-hydroxy-4-phenylbutane;(2S,3S)-(3-hydroxy)pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester;(2S,3S)-3-(N-benzyloxycarbonyl)amino-3-benzyl-2-hydroxy-1-chloropropane;N-benzyloxycarbonyl-3(S)-amino-1-chloro-4-phenyl-2(S)-butanol;Benzyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate;Carbamic acid,N-[(1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl]-,phenylmethyl ester;(2S,3S)-1-chloro-3-benzyloxycarbonylamino-3-benzyl-2-propanol;(2S,3S)-1-chloro-2-hydroxy-3-N-benzyloxycarbonylamino-4-phenylbutane;

Suppliers and Price of FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Fmoc-(2S,3S)-3-hydroxypyrrolidine-2-carboxylicacid
1g
$ 650.00

Matrix Scientific
Fmoc-(2S,3S)-3-hydroxypyrrolidine-2-carboxylicacid
5g
$ 2220.00

Crysdot
(2S,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylicacid 95+%
5g
$ 1328.00

Crysdot
(2S,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylicacid 95+%
1g
$ 332.00

Atlantic Research Chemicals
(2S,3S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylicacid 95%
1gm:
$ 519.58

American Custom Chemicals Corporation
FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 95.00%
1G
$ 1523.20

American Custom Chemicals Corporation
FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 95.00%
5MG
$ 521.00

Total 11 raw suppliers

Chemical Property of FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

Chemical Property:

PSA：87.07000
LogP:2.39320

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-(2S,3S)-3-hydroxypyrrolidine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

There total 5 articles about FMOC-(2S,3S)-3-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 4298-08-2
trans-3-hydroxy-L-proline

: 296774-32-8
(2S,3S)-(3-hydroxy)pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 0 - 20 ℃; for 9h;
DOI:10.1021/ol007029s

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: (2S,3R,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-3,4-dihydroxypyrrolidine-2-carboxylic acid

: 296774-32-8
(2S,3S)-(3-hydroxy)pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: L-proline; With ferrous(II) sulfate heptahydrate; sodium L-ascorbate; α-ketoglutaric acid disodium salt; In aq. phosphate buffer; at 37 ℃; pH=7.5; Enzymatic reaction;

(fluorenylmethoxy)carbonyl chloride; In aq. phosphate buffer; acetonitrile; at 37 ℃; pH=7.5;
DOI:10.1021/acs.oprd.1c00405

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 296774-32-8
(2S,3S)-(3-hydroxy)pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium L-ascorbate; α-ketoglutaric acid disodium salt; ferrous(II) sulfate heptahydrate / aq. phosphate buffer / 30 °C / pH 7.5 / Enzymatic reaction

2: acetonitrile / 0.17 h / 30 °C

With ferrous(II) sulfate heptahydrate; sodium L-ascorbate; α-ketoglutaric acid disodium salt; In aq. phosphate buffer; acetonitrile;
DOI:10.1021/acs.oprd.1c00405