2,2-Dichloro-N,N-diethylacetamide

Base Information

• Chemical Name: 2,2-Dichloro-N,N-diethylacetamide
• CAS No.: 921-88-0
• Molecular Formula: C6H11 Cl2 N O
• Molecular Weight: 184.065
• European Community (EC) Number: 213-072-5
• NSC Number: 50938
• DSSTox Substance ID: DTXSID20238863
• Nikkaji Number: J298.478D
• Wikidata: Q83121201
• Mol file: 921-88-0.mol

Synonyms:2,2-Dichloro-N,N-diethylacetamide;921-88-0;EINECS 213-072-5;Acetamide, 2,2-dichloro-N,N-diethyl-;AI3-32447;NSC50938;C6H11Cl2NO;N,N-Diethyldichloroacetamide;SCHEMBL11897019;DTXSID20238863;a,a-dichloroacetic acid diethylamide;NSC 50938;NSC-50938;AKOS003851352;alpha,alpha-Dichloro-N,N-diethylacetylacetamide

Chemical Property of 2,2-Dichloro-N,N-diethylacetamide

Chemical Property:

• Vapor Pressure: 0.135mmHg at 25°C
• Boiling Point: 217.1°Cat760mmHg
• PKA: -1.36±0.70(Predicted)
• Flash Point: 85.1°C
• PSA: 20.31000
• Density: 1.186g/cm³
• LogP: 1.65850
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 183.0217694
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C(=O)C(Cl)Cl

Technology Process of 2,2-Dichloro-N,N-diethylacetamide

There total 10 articles about 2,2-Dichloro-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dichloroacethyl chloride (79-36-7) + diethylamine (109-89-7) → N,N-diethyldichloroacetamide (921-88-0)

Guidance literature:

In dichloromethane; for 5h; Heating;

DOI:10.1021/jo701417z

Reference yield: 95.0%

trichloroethylene epoxide (16967-79-6) + diethylamine (109-89-7) → N,N-diethyldichloroacetamide (921-88-0)

Guidance literature:

In tetrachloromethane; at -20 ℃; for 0.333333h;

Reference yield: 86.0%

2,2-Dichloro-N,N-diethyl-2-trimethylsilanyl-acetamide → N,N-diethyldichloroacetamide (921-88-0)

Guidance literature:

With hydrogenchloride; In water; for 120h;

upstream raw materials:

dichloroacethyl chloride

diethylamine

4-chloro-3,3,4-trifluoro-2-methyl-butan-1-ol

2,2-dichloro-1,1-difluoroethyldiethylamine

Downstream raw materials:

(E)-N,N-Diethyl-4-phenylpent-2-enamide

2,2-dichloro-N,N-diethyl-3-phenylpropionamide

(E)-3-cyclohexyl-N,N-diethylacrylamide

(E)-N,N-diethyl-3-phenylacrylamide