BENZYL GLYCOLATE

Base Information

• Chemical Name: BENZYL GLYCOLATE
• CAS No.: 30379-58-9
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2918199090
• Mol file: 30379-58-9.mol

Synonyms:O-benzylglycolic acid;Acetic acid,hydroxy-,phenylmethyl ester;glycolic acid benzyl ester;2-hydroxybenzyl acetate;Benzyl (1)-glycolate;Benzyl glycolate;Benzyl hydroxyacetate;

Chemical Property of BENZYL GLYCOLATE

Chemical Property:

• Vapor Pressure: 0.00296mmHg at 25°C
• Refractive Index: n20/D 1.527(lit.)
• Boiling Point: 136oC14 mm Hg(lit.)
• PKA: 12.96±0.10(Predicted)
• Flash Point: >230 °F
• PSA: 46.53000
• Density: 1.171 g/mL at 25oC(lit.)
• LogP: 0.72210
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)

Purity/Quality:

96%, ^*data from raw suppliers

Benzyl Glycolate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Benzyl Glycolate was utilized as a potential moiety for the preparation of phosphonate dipeptides as potential inhibitors of VanX. Benzyl glycolate may be used for the synthesis of the methyl [2-(2′-benzyloxy-2′-oxoethyl)-5-acetamido-4,7,8,9- tetra-O-acetyl-3,5-dideoxy-α- and -β-D-glycero-D-galacto-2-nonulopyranosid]onate. It may be used for the preparation of monosaccharide building blocks. It may also be used for the synthesis of the following new polymeric phosphazenes having pendent esters of glycolic or lactic acid as side units:poly[bis(ethyl glycolato)phosphazene]poly[bis(ethyl lactato)phosphazene]poly[bis(benzyl glycolato)phosphazene]poly[bis(benzyl lactato)phosphazene]

Technology Process of BENZYL GLYCOLATE

There total 10 articles about BENZYL GLYCOLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

glycolic Acid (79-14-1) + benzyl bromide (100-39-0) → benzyl glycolate (30379-58-9)

Guidance literature:

glycolic Acid; With caesium carbonate; In methanol; water; at 20 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2011.06.062

Reference yield: 88.0%

glycolic acid methyl ester (96-35-5) + benzyl alcohol (100-51-6,185532-71-2) → benzyl glycolate (30379-58-9)

Guidance literature:

With n-butylstannoic acid; at 50 - 200 ℃;

Reference yield: 80.0%

glycolic Acid (79-14-1) + benzyl alcohol (100-51-6,185532-71-2) → benzyl glycolate (30379-58-9)

Guidance literature:

benzyl alcohol; With toluene-4-sulfonic acid; In benzene; for 0.5h; Reflux;

glycolic Acid; In benzene; Reflux;

DOI:10.1016/j.bmcl.2011.10.094

upstream raw materials:

glycolic Acid

benzyl chloride

glycolic acid methyl ester

sodium phenyl-methanolate

Downstream raw materials:

benzyl <(trifluoromethyl)sulfonyloxy>acetate

[[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(2-cyano-ethoxy)-phosphoryloxy]-acetic acid benzyl ester

Benzyl<<(trichloroethoxy)carbonyl>oxy>acetate

glycolic Acid

Refernces

• 1、 Monteith, John J.,Rousseaux, Sophie A. L.. "Ni-Catalyzed C(sp3)–O Arylation of α-Hydroxy Esters". supporting information. p. 9485 - 9489. Retrieved 2021/12/09.
• 2、 -. "Preparation method and application of hydroxy acid alkyl ester". Paragraph 0031-0033. . Retrieved 2020/06/16.