1-Methyl-2-thiophen-2-yl-ethylamine

Base Information

• Chemical Name: 1-Methyl-2-thiophen-2-yl-ethylamine
• CAS No.: 30433-93-3
• Molecular Formula: C7H11NS
• Molecular Weight: 141.23400
• Hs Code.: 2934999090
• UNII: N60H4ZDD14
• DSSTox Substance ID: DTXSID80424381
• Wikipedia: Thiopropamine
• Wikidata: Q7784689
• ChEMBL ID: CHEMBL95500
• Mol file: 30433-93-3.mol

Synonyms:1-(3,3-diphenylpropyl)amino-3-phenylthiopropane;thiopropamine

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Chemical Property of 1-Methyl-2-thiophen-2-yl-ethylamine

Chemical Property:

• Vapor Pressure: 0.188mmHg at 25°C
• Boiling Point: 210.8oC at 760 mmHg
• Flash Point: 81.3oC
• PSA: 54.26000
• Density: 1.067g/cm3
• LogP: 2.33810
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 141.06122053
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CS1)N

Technology Process of 1-Methyl-2-thiophen-2-yl-ethylamine

There total 10 articles about 1-Methyl-2-thiophen-2-yl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

→ (+/-)-1-(methyl-2-thien-2-yl)ethylamine (30433-93-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Reflux; Cooling with ice;

Reference yield: 48.0%

2-(2-nitroprop-1-enyl)thiophene (6937-35-5) → (+/-)-1-(methyl-2-thien-2-yl)ethylamine (30433-93-3)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/jm0210818

Reference yield: 32.0%

1-(thiophen-2-yl)propan-2-one (15022-18-1) + ammonia (7664-41-7) → (+/-)-1-(methyl-2-thien-2-yl)ethylamine (30433-93-3)

Guidance literature:

1-(thiophen-2-yl)propan-2-one; ammonia; With titanium(IV) isopropylate; In ethanol; at 20 ℃; for 16h; Inert atmosphere;

With sodium tetrahydroborate; at 20 ℃; for 3h;

DOI:10.1002/adsc.202100351

upstream raw materials:

1-(thiophen-2-yl)propan-2-one

(E)-2-(2-nitroprop-1-en-1-yl)thiophene

2-(2-nitroprop-1-enyl)thiophene

thiophene-2-carbaldehyde