Benzamide, 2-(2-methoxyethoxy)-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoro methyl)phenoxy]-1-piperidinyl]sulfonyl]-

Base Information

Chemical Name:Benzamide, 2-(2-methoxyethoxy)-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoro methyl)phenoxy]-1-piperidinyl]sulfonyl]-
CAS No.:308386-45-0
Molecular Formula:C₂₇H₃₃F₃N₂O₈S
Molecular Weight:602.629
Hs Code.:
Mol file:308386-45-0.mol

Synonyms:

Suppliers and Price of Benzamide, 2-(2-methoxyethoxy)-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoro methyl)phenoxy]-1-piperidinyl]sulfonyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzamide, 2-(2-methoxyethoxy)-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoro methyl)phenoxy]-1-piperidinyl]sulfonyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzamide, 2-(2-methoxyethoxy)-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoro methyl)phenoxy]-1-piperidinyl]sulfonyl]-

There total 6 articles about Benzamide, 2-(2-methoxyethoxy)-N-[(tetrahydro-2H-pyran-2-yl)oxy]-6-[[4-[4-(trifluoro methyl)phenoxy]-1-piperidinyl]sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28033-37-6
4-[4-(trifluoromethyl)-phenoxy]piperidine

: 308386-45-0
2-(2-methoxy-ethoxy)-N-(tetrahydro-pyran-2-yloxy)-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / TEA; DMAP / CH₂Cl₂

2: 71 percent / 1-methyl-pyrrolidin-2-one / 20 h / 115 °C

3: t-BuLi / 0 °C

4: oxalyl chloride / CH₂Cl₂

5: pyridine / CH₂Cl₂

With pyridine; dmap; oxalyl dichloride; TEA; tert.-butyl lithium; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/S0960-894X(01)00487-5

Reference yield:

: 701-27-9
3-fluorobenzene-1-sulfonyl chloride

: 308386-45-0
2-(2-methoxy-ethoxy)-N-(tetrahydro-pyran-2-yloxy)-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / TEA; DMAP / CH₂Cl₂

2: 71 percent / 1-methyl-pyrrolidin-2-one / 20 h / 115 °C

3: t-BuLi / 0 °C

4: oxalyl chloride / CH₂Cl₂

5: pyridine / CH₂Cl₂

With pyridine; dmap; oxalyl dichloride; TEA; tert.-butyl lithium; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/S0960-894X(01)00487-5

Reference yield:

: 308386-31-4
1-(3-fluoro-benzenesulfonyl)-4-(4-trifluoromethyl-phenoxy)-piperidine

: 308386-45-0
2-(2-methoxy-ethoxy)-N-(tetrahydro-pyran-2-yloxy)-6-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / 1-methyl-pyrrolidin-2-one / 20 h / 115 °C

2: t-BuLi / 0 °C

3: oxalyl chloride / CH₂Cl₂

4: pyridine / CH₂Cl₂

With pyridine; oxalyl dichloride; tert.-butyl lithium; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/S0960-894X(01)00487-5