Glycine, N-benzoyl-, 4-nitrophenyl ester

Base Information

• Chemical Name: Glycine, N-benzoyl-, 4-nitrophenyl ester
• CAS No.: 3101-11-9
• Molecular Formula: C15H12N2O5
• Molecular Weight: 300.271
• Mol file: 3101-11-9.mol

Synonyms:

Chemical Property of Glycine, N-benzoyl-, 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-benzoyl-, 4-nitrophenyl ester

There total 5 articles about Glycine, N-benzoyl-, 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → Bz-Gly-ONPh (3101-11-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In chloroform; at 10 ℃; for 3h;

DOI:10.1021/ja00307a034

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + hippuryl chloride (53587-10-3) → Bz-Gly-ONPh (3101-11-9)

Guidance literature:

With pyridine;

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → Bz-Gly-ONPh (3101-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Py / benzene; toluene

2: Py

With pyridine; In toluene; benzene;

upstream raw materials:

4-nitro-phenol

hippuryl chloride

Hippuric Acid

bis-(p-nitrophenyl) carbonate

Downstream raw materials:

(R)-2-(2-Benzoylamino-acetylamino)-propionic acid

N-hippuroyl-3-phenyl-alanine

N-benzoylglycyl-L-phenylalanine

Nα-(Benzoylglycyl)-4-cyanphenylalanin

Refernces

• 1、 Sasikmnar,Kumar,Arnnan,Rajasekharaa Pillai. "Synthesis and optimization of tri(propylene glycol) glycerolate diacrylate cross-linked polystyrene resin in polypeptide synthesis: Role of the macromolecular support in solid phase peptide synthesis". . p. 2886 - 2895. Retrieved 2002.
• 2、 Voigt,Wagner. "Synthesis of Nα-(benzoylglycyl)- and Nα-(benzyloxycarbonyl-glycyl)-4-aminodiphenylalanine as thrombin inhibitors". . p. 527 - 529. Retrieved 2007/10/02.