4-(3-PYRIDYL)ANILINE

Base Information

• Chemical Name: 4-(3-PYRIDYL)ANILINE
• CAS No.: 82261-42-5
• Molecular Formula: C11H10N2
• Molecular Weight: 170.214
• Hs Code.: 2933399990
• Mol file: 82261-42-5.mol

Synonyms:4-pyridin-3-ylaniline;

Chemical Property of 4-(3-PYRIDYL)ANILINE

Chemical Property:

• Vapor Pressure: 0.00014mmHg at 25°C
• Melting Point: 115oC
• Boiling Point: 333℃
• Flash Point: 182℃
• PSA: 38.91000
• Density: 1.133
• LogP: 2.91200
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Pyridin-3-ylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-PYRIDYL)ANILINE

There total 25 articles about 4-(3-PYRIDYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-pyridylboronic acid (1692-25-7) + 4-bromo-aniline (106-40-1) → 4-pyridin-3-ylaniline (82261-42-5)

Guidance literature:

With potassium phosphate; palladium dichloride; S-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine; In butan-1-ol; at 100 ℃; for 20h; Inert atmosphere;

DOI:10.1002/ejoc.200900038

Reference yield: 99.0%

3-(tributylstannyl)pyridine (59020-10-9) + 4-bromo-aniline (106-40-1) → 4-pyridin-3-ylaniline (82261-42-5)

Guidance literature:

With copper(l) iodide; C₃₇H₅₁ClFeNPPd; cesium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tet.2012.10.080

Reference yield: 98.0%

4-(3'-pyridinyl)-1-chlorobenzene (5957-97-1) → 4-pyridin-3-ylaniline (82261-42-5)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 110 ℃; for 1h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201000526

upstream raw materials:

3-(4'-nitrophenyl)pyridine

3-(4-dimethylureidophenyl)pyridine

3-Diethylboranylpyridine

4-bromo-aniline

Downstream raw materials:

N-(4-propoxy-phenyl)-N'-(4-[3]pyridyl-phenyl)-thiourea

N-(4-butoxy-phenyl)-N'-(4-[3]pyridyl-phenyl)-thiourea

3-phenylpyridine

4-(pyridin-3-yl)phenol

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6". Paragraph 00499-00500. . Retrieved 2021/09/04.
• 2、 -. "NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF". Paragraph 0069; 0097. . Retrieved 2021/11/04.