5957-97-1

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-CHLORO-PHENYL)-PYRIDINE is used as a building block for the synthesis of various pharmaceutical drugs and active pharmaceutical ingredients (APIs). Its unique structure contributes to the development of new medications with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 3-(4-CHLORO-PHENYL)-PYRIDINE serves as an intermediate in the production of various agrochemicals. Its role in this sector is crucial for creating compounds that protect crops and enhance agricultural productivity.
Used in Fine Chemicals Synthesis:
3-(4-CHLORO-PHENYL)-PYRIDINE is also utilized as an intermediate in the synthesis of other fine chemicals. Its presence in these chemical processes is essential for creating high-quality specialty chemicals used across different industries.

InChI:InChI=1/C11H8ClN/c12-11-5-3-9(4-6-11)10-2-1-7-13-8-10/h1-8H

Upstream product

• 110-86-1 pyridine 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 1120-90-7 3-iodopyridine 
• 108-90-7 chlorobenzene 
• 106-39-8 bromochlorobenzene 
• 89878-14-8 3-Diethylboranylpyridine 
• 626-55-1 3-Bromopyridine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 56049-46-8 N’-(p-chlorophenyl) p-toluenesulfonyl hydrazide 
• 5575-51-9 tris(4-chlorophenyl)bismuthane 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 106-47-8 4-chloro-aniline 
• 110213-25-7 C₆H₄ClN₂O^(1-)*Na⁽¹⁺⁾ 

Downstream Products

• 929203-04-3 3-[4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyridine 
• 82261-42-5 4-pyridin-3-ylaniline 

Relevant academic research and scientific papers

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

Phenylpyridine derivative (by machine translation)

[Problem] in a photoelectric conversion element, the heat resistance can be improved phenylpyridine derivative. (1) Represented by the formula [a] phenylpyridine derivative (A ring, B, C D and is, a pyridine ring, each of the carbon atoms contained in R1 - R11, hydrogen, straight-chain alkyl group, a branched alkyl group, an aryl group, such as one selected from binding. ). Figure 1 [drawing] (by machine translation)

Ferrocenyl palladacycles derived from unsymmetrical pincer-type ligands: Evidence of Pd(0) nanoparticle generation during the Suzuki-Miyaura reaction and applications in the direct arylation of thiazoles and isoxazoles

A new family of ferrocenyl-palladacycle complexes Pd(L1)Cl (Pd1) and Pd(L2)Cl (Pd2) were synthesized and characterized by UV-visible, IR, ESI-MS, and NMR spectral studies. The molecular structures of Pd1 and Pd2 were determined by X-ray crystallographic studies. Palladacycle catalyzed Suzuki-Miyaura cross-coupling reactions were investigated utilizing the derivatives of phenylboronic acids and substituted chlorobenzenes. Mechanistic investigation authenticated the generation of Pd(0) nanoparticles during the catalytic cycle and the nanoparticles were characterized by XPS, SEM and TEM analysis. Direct C-H arylation of thiazole and isoxazole derivatives employing these ferrocenyl-palladacycle complexes was examined. The reaction model for the arylation reaction implicating the in situ generation of Pd(0) nanoparticles was proposed.

Radical Arylation of Anilines and Pyrroles via Aryldiazotates

The radical arylation of anilines and pyrroles can be achieved under transition-metal- and catalyst-free conditions by using aryldiazotates in strongly alkaline aqueous solutions. The aryldiazotates act as protected diazonium ions, which do not undergo azo coupling with electron-rich aromatic substrates, but can still serve as an aryl radical source at slightly elevated temperatures. Based on an improved preparation of aryldiazotates in aqueous solution, homolytic aromatic substitutions of anilines and pyrroles were conducted with good overall yields and high regioselectivity. Moreover, DFT calculations provided further mechanistic insights.

A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors

The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879.

Carboxyamido/carbene ligated palladium (II) complex: A versatile catalyst for the synthesis of aryl-substituted heteroarenes

Carboxy amido/carbene ligated Pd-complex catalyzed Suzuki-Miyaura cross-coupling of aryl-boronic acids with heteroaryl bromides is described. The protocol has a broad substrate scope that includes electron-rich, electron-deficient and sterically hindered arylboronic acids and heteroaryl bromides. The catalytic activity of the catalyst has been further investigated in the coupling of 2,6-dibromopyridine with arylboronic acids.

Cross-coupling study of iodo/chloropyridines and 2-chloroquinoline with atom-economic triarylbismuth reagents under Pd-catalysis

This study describes the palladium-catalyzed couplings of iodopyridines, chloropyridines, and chloroquinoline with atom-economic BiAr3 reagents in sub-stoichiometric loadings. Mono-arylations of iodo and chloropyridines produced arylpyridines i

NOVEL COMPOUND, ORGANIC ELECTROLUMINESCENT ELEMENT, ILLUMINATION DEVICE AND DISPLAY DEVICE

PROBLEM TO BE SOLVED: To provide novel long-life compounds, organic electroluminescent elements, illumination devices and display devices. SOLUTION: This invention relates to a compound represented by formula (1) (where rings A, B, C, and D are pyridine rings; R1-11 are H, an alkyl group, an aryl group or the like). COPYRIGHT: (C)2016,JPO&INPIT

METHOD OF SYNTHESIS MOLECULES USING CATALYST AND COMPOSITES THEREOF

A method to synthesis molecules is provided. The method employs a catalyst for a cross- coupling react ion to obtain the molecule. The method comprises coupling boronic acid and halide in presence of the catalyst having graphite oxide supported palladium nanoparticles, a solvent and a base by heating. The heating is performed at a temperature lower than the temperature at which the graphite oxide deforms. The molecule is a biaryl. The method further provides obtaining complexs such as boscalid, telmisartan, valsartan, and SPPARMγ.

Triarylbismuthanes as threefold aryl-transfer reagents in regioselective cross-coupling reactions with bromopyridines and quinolines

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalysed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both symmetrical and unsymmetrical diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalysed conditions. Copyright