3-(Piperidin-4-yloxy)pyridine

Base Information

• Chemical Name: 3-(Piperidin-4-yloxy)pyridine
• CAS No.: 310881-48-2
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60477779
• Nikkaji Number: J1.320.991J
• Wikidata: Q82310688
• Mol file: 310881-48-2.mol

Synonyms:3-(Piperidin-4-yloxy)pyridine;310881-48-2;3-(PIPERIDIN-4-YLOXY)-PYRIDINE;3-(4-piperidinyloxy)pyridine;Pyridine, 3-(4-piperidinyloxy)-;3-piperidin-4-yloxypyridine;SCHEMBL2241148;3-((4-piperidinyl)oxy)pyridine;DTXSID60477779;URPWHVAXGCXZOR-UHFFFAOYSA-N;AR2312;MFCD08059774;AKOS000558648;SB41199;AS-45323;3-(piperidin-4-yloxy)-pyridine, AldrichCPR;BB 0260445;CS-0171168;FT-0703494;EN300-393787

Chemical Property of 3-(Piperidin-4-yloxy)pyridine

Chemical Property:

• Vapor Pressure: 0.00103mmHg at 25°C
• Boiling Point: 301.8oC at 760 mmHg
• PKA: 9.58±0.10(Predicted)
• Flash Point: 136.3oC
• PSA: 34.15000
• Density: 1.078g/cm3
• LogP: 1.54120
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 178.110613074
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

97% ^*data from raw suppliers

3-(Piperidin-4-yloxy)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1OC2=CN=CC=C2
• Uses: 3-(Piperidin-4-yloxy)pyridine is used in preparation of the inhibitor containing bicyclic derivative and their medical applications.

Technology Process of 3-(Piperidin-4-yloxy)pyridine

There total 3 articles about 3-(Piperidin-4-yloxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl 4-(3'-pyridinyloxy)-1-piperidinecarboxylate (310881-47-1) → 3-((4-piperidinyl)oxy)pyridine (310881-48-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(00)00168-2

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → 3-((4-piperidinyl)oxy)pyridine (310881-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1: DIEA / dioxane; H₂O

2: PPh₃; DEAD / tetrahydrofuran

3: TFA / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1: Acylation / 2: Mitsunobu reaction / 3: deprotection;

DOI:10.1016/S0960-894X(00)00168-2

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 3-((4-piperidinyl)oxy)pyridine (310881-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: PPh₃; DEAD / tetrahydrofuran

2: TFA / CH₂Cl₂

With triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction / 2: deprotection;

DOI:10.1016/S0960-894X(00)00168-2

upstream raw materials:

1,1-dimethylethyl 4-(3'-pyridinyloxy)-1-piperidinecarboxylate

4-HYDROXYPIPERIDINE

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

(S)-3-{4-[4-(pyridin-3-yloxy)-piperidin-1-ylmethyl]-phenyl}-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine trifluoroacetate