Technology Process of trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester
There total 8 articles about trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C26H29F2N3O5;
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 18h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
1.2: 19 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C
3.1: hydrogenchloride / water; acetone / 15 h / 20 °C
4.1: sodium tetrahydroborate; methanol / 1 h / 0 °C
5.1: pyridine / dichloromethane / 0 - 20 °C
5.2: 3.5 h / 20 °C
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C
7.1: triethylamine / dichloromethane / 0.17 h / 20 °C
7.2: 0.67 h
8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C
With
pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; water; hydrogen; sodium hydride; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 0 - 20 °C
1.2: 3.5 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C
3.1: triethylamine / dichloromethane / 0.17 h / 20 °C
3.2: 0.67 h
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C
With
pyridine; water; hydrogen; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
